4-(p-Tolyl)piperidin-4-ol

Base Information

• Chemical Name: 4-(p-Tolyl)piperidin-4-ol
• CAS No.: 57988-60-0
• Molecular Formula: C12H17NO
• Molecular Weight: 191.273
• Hs Code.: 2933399090
• European Community (EC) Number: 261-066-6
• NSC Number: 83238
• UNII: 2T4AA338QN
• DSSTox Substance ID: DTXSID10206713
• Nikkaji Number: J31.371H
• Wikidata: Q83080575
• Mol file: 57988-60-0.mol

Synonyms:4-(4-methylphenyl)piperidin-4-ol;57988-60-0;4-(p-Tolyl)piperidin-4-ol;4-p-Tolyl-piperidin-4-ol;2T4AA338QN;4-(4-methylphenyl)-4-piperidinol;EINECS 261-066-6;NSC-83238;4-hydroxy-4-(4-methylphenyl)piperidine;4-p-Tolylpiperidin-4-ol;NSC83238;4-Piperidinol, 4-(4-methylphenyl)-;UNII-2T4AA338QN;SCHEMBL613058;DTXSID10206713;TQR1244;MFCD00087127;NSC 83238;STK504175;AKOS000266474;SB41325;4-hydroxy-4-(4-methylphenyl)-piperidine;LS-02489;BB 0258874;CS-0453837;FT-0762517;F79465;EN300-2693297

Chemical Property of 4-(p-Tolyl)piperidin-4-ol

Chemical Property:

• Vapor Pressure: 4.62E-05mmHg at 25°C
• Boiling Point: 335.7°Cat760mmHg
• Flash Point: 133.9°C
• PSA: 32.26000
• Density: 1.072g/cm³
• LogP: 1.89480
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 191.131014166
• Heavy Atom Count: 14
• Complexity: 179

Purity/Quality:

98%min ^*data from raw suppliers

4-Hydroxy-4-(4-methylphenyl)piperidineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C2(CCNCC2)O

Technology Process of 4-(p-Tolyl)piperidin-4-ol

There total 9 articles about 4-(p-Tolyl)piperidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

tert-butyl 4-hydroxy-4-(p-tolyl)piperidine-1-carboxylate (1260882-14-1) → 4-hydroxy-4-(4-methylphenyl)-piperidine (57988-60-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

DOI:10.1021/acs.jmedchem.9b00864

Reference yield: 57.0%

1-benzyl-4-(4-methylphenyl)piperidin-4-ol (13299-35-9) → 4-hydroxy-4-(4-methylphenyl)-piperidine (57988-60-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 2h; under 2844.31 Torr;

Reference yield: 29.0%

→ 4-hydroxy-4-(4-methylphenyl)-piperidine (57988-60-0)

Guidance literature:

upstream raw materials:

4-Bromo-4-p-tolyl-piperidine

1-benzyl-4-(4-methylphenyl)piperidin-4-ol

1-phenylmethyl-4-piperidone

para-bromotoluene

Downstream raw materials:

moperone

4-(4-hydroxy-4-p-tolyl-piperidino)-1-phenyl-butan-1-one

2-(4-Hydroxy-4-p-tolyl-piperidin-1-yl)-1-(4-triisopropylsilanyloxy-phenyl)-propan-1-one

1-benzyl-4-(4-methylphenyl)piperidin-4-ol