4(1H)-Pyrimidinone, 2,3-dihydro-1-((2-hydroxyethoxy)methyl)-5-(1-methylethyl)-6-((3-methylphenyl)seleno)-2-thioxo-

Base Information

Chemical Name:4(1H)-Pyrimidinone, 2,3-dihydro-1-((2-hydroxyethoxy)methyl)-5-(1-methylethyl)-6-((3-methylphenyl)seleno)-2-thioxo-
CAS No.:172255-81-1
Molecular Formula:C17H22N2O3SSe
Molecular Weight:413.3932
Hs Code.:
DSSTox Substance ID:DTXSID40169221

Synonyms:172255-81-1;4(1H)-Pyrimidinone, 2,3-dihydro-1-((2-hydroxyethoxy)methyl)-5-(1-methylethyl)-6-((3-methylphenyl)seleno)-2-thioxo-;5-Methylethyl-1-((2-hydroxyethoxy)methyl)-6-((3-methylphenyl)selenenyl)-2-thioxo-1,3-dihydropyrimidin-4-one;4(1H)-Pyrimidinone, 2,3-dihydro-1-[(2-hydroxyethoxy)methyl]-5-(1-methylethyl)-6-[(3-methylphenyl)seleno]-2-thioxo-;5-Methylethyl-1-[(2-hydroxyethoxy)methyl]-6-[(3-methylphenyl)selenenyl]-2-thioxo-1,3-dihydropyrimidin-4-one;SCHEMBL9016475;DTXSID40169221;1-(2-hydroxyethoxymethyl)-5-isopropyl-6-(m-tolylselanyl)-2-thioxo-pyrimidin-4-one

Suppliers and Price of 4(1H)-Pyrimidinone, 2,3-dihydro-1-((2-hydroxyethoxy)methyl)-5-(1-methylethyl)-6-((3-methylphenyl)seleno)-2-thioxo-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4(1H)-Pyrimidinone, 2,3-dihydro-1-((2-hydroxyethoxy)methyl)-5-(1-methylethyl)-6-((3-methylphenyl)seleno)-2-thioxo-

Chemical Property:

Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:414.05164
Heavy Atom Count:24
Complexity:510

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=CC=C1)[Se]C2=C(C(=O)NC(=S)N2COCCO)C(C)C

Technology Process of 4(1H)-Pyrimidinone, 2,3-dihydro-1-((2-hydroxyethoxy)methyl)-5-(1-methylethyl)-6-((3-methylphenyl)seleno)-2-thioxo-

There total 8 articles about 4(1H)-Pyrimidinone, 2,3-dihydro-1-((2-hydroxyethoxy)methyl)-5-(1-methylethyl)-6-((3-methylphenyl)seleno)-2-thioxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1-[[2-(tert-butyldimethylsiloxy)ethoxy]methyl]-5-isopropyl-2-thiouracil

: 69468-42-4
bis(3-methylphenyl) diselenide

: 172255-81-1
1-[(2-hydroxyethoxy)methyl]-5-isopropyl-6-[(3-methylphenyl)-selenenyl]-2-thiouracil

Guidance literature:

Reference yield:

: 1026276-46-9
1-[2-(tert-Butyl-dimethyl-silanyloxy)-ethoxymethyl]-5-isopropyl-2-thioxo-6-m-tolylselanyl-2,3-dihydro-1H-pyrimidin-4-one

: 172255-81-1
1-[(2-hydroxyethoxy)methyl]-5-isopropyl-6-[(3-methylphenyl)-selenenyl]-2-thiouracil

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; cyclohexane; for 2h; Yield given; Ambient temperature;
DOI:10.1002/jhet.5570330446

Reference yield:

: 18718-34-8
5-isopropyl-2-thiouracil

: 172255-81-1
1-[(2-hydroxyethoxy)methyl]-5-isopropyl-6-[(3-methylphenyl)-selenenyl]-2-thiouracil

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 1,1,1,3,3,3-hexamethyldisilazane, (NH₄)2SO₄, 2.) CsI / 1.) dichloromethane, 15, reflux, 2.) dichloromethane, MeCN, 3 h, RT

2: imidazole / dimethylformamide / 16 h / Ambient temperature

3: 1.) LDA / 1.) THF, cyclohexane, -70 deg C, 1 h, 2.) THF, cyclohexane, 1 h, -70 deg C

4: conc. aq. HCl / cyclohexane; tetrahydrofuran / 2 h / Ambient temperature

With 1H-imidazole; hydrogenchloride; ammonium sulfate; isocyanate de chlorosulfonyle; 1,1,1,3,3,3-hexamethyl-disilazane; lithium diisopropyl amide; In tetrahydrofuran; cyclohexane; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570330446