2-amino-9-(1,6-dihydroxyhexan-3-yl)-3,9-dihydro-6H-purin-6-one

Base Information

• Chemical Name: 2-amino-9-(1,6-dihydroxyhexan-3-yl)-3,9-dihydro-6H-purin-6-one
• CAS No.: 144175-45-1
• Molecular Formula: C₁₁H₁₇N₅O₃
• Molecular Weight: 267.288
• Mol file: 144175-45-1.mol

Synonyms:6H-Purin-6-one,2-amino-1,9-dihydro-9-[4-hydroxy-1-(2-hydroxyethyl)butyl]-, (?à)-

Chemical Property of 2-amino-9-(1,6-dihydroxyhexan-3-yl)-3,9-dihydro-6H-purin-6-one

Chemical Property:

• Vapor Pressure: 1.59E-17mmHg at 25°C
• Boiling Point: 645.2°C at 760 mmHg
• Flash Point: 344°C
• PSA: 131.04000
• Density: 1.6g/cm³
• LogP: -0.25980

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-amino-9-(1,6-dihydroxyhexan-3-yl)-3,9-dihydro-6H-purin-6-one

There total 4 articles about 2-amino-9-(1,6-dihydroxyhexan-3-yl)-3,9-dihydro-6H-purin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,5-diamino-6-chloro-4-<(cyclohex-3-en-1-yl)amino>pyrimidine (131853-60-6) → 9-(dihydroxy-1,6-hex-3-yl)guanine (144175-45-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 75 percent / 12N HCl / N,N-dimethyl-acetamide / Ambient temperature

2: 80 percent / 1M HCl / 6 h / Heating

3: N-methylmorpholine N-oxide, OsO₄ / H₂O; methanol; 2-methyl-propan-2-ol / 0.75 h / 90 °C

4: 1.) sodium periodate 2.) sodium borohydride / 1.) H₂O, 3 h, r.t. 2.) H₂O, 2 h, 0 deg C

With hydrogenchloride; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; 4-methylmorpholine N-oxide; hydrogenchloride; In methanol; N,N-dimethyl acetamide; water; tert-butyl alcohol;

DOI:10.1002/jhet.5570270652

Reference yield:

2-amino-6-chloro-9H-9-(cyclohex-3-en-1-yl)purine (131853-61-7) → 9-(dihydroxy-1,6-hex-3-yl)guanine (144175-45-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / 1M HCl / 6 h / Heating

2: N-methylmorpholine N-oxide, OsO₄ / H₂O; methanol; 2-methyl-propan-2-ol / 0.75 h / 90 °C

3: 1.) sodium periodate 2.) sodium borohydride / 1.) H₂O, 3 h, r.t. 2.) H₂O, 2 h, 0 deg C

With hydrogenchloride; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; 4-methylmorpholine N-oxide; In methanol; water; tert-butyl alcohol;

DOI:10.1002/jhet.5570270652

Reference yield:

9-(cyclohex-3-en-1-yl)guanine (131853-63-9) → 9-(dihydroxy-1,6-hex-3-yl)guanine (144175-45-1)

Guidance literature:

Multi-step reaction with 2 steps

1: N-methylmorpholine N-oxide, OsO₄ / H₂O; methanol; 2-methyl-propan-2-ol / 0.75 h / 90 °C

2: 1.) sodium periodate 2.) sodium borohydride / 1.) H₂O, 3 h, r.t. 2.) H₂O, 2 h, 0 deg C

With sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; 4-methylmorpholine N-oxide; In methanol; water; tert-butyl alcohol;

DOI:10.1002/jhet.5570270652

upstream raw materials:

2,5-diamino-6-chloro-4-<(cyclohex-3-en-1-yl)amino>pyrimidine

2-amino-6-chloro-9H-9-(cyclohex-3-en-1-yl)purine

9-(cyclohex-3-en-1-yl)guanine