Ucn-01

Base Information

• Chemical Name: Ucn-01
• CAS No.: 121569-61-7
• Molecular Formula: C28H26 N4 O4
• Molecular Weight: 482.537
• DSSTox Substance ID: DTXSID60923867
• Nikkaji Number: J624.304E
• Wikidata: Q82897962
• Pharos Ligand ID: 8NDTBCWTZWDS
• Metabolomics Workbench ID: 98538
• ChEMBL ID: CHEMBL574737
• Mol file: 121569-61-7.mol

Synonyms:7-epi-hydroxystaurosporine;7-hydroxy-staurosporine;7-hydroxystaurosporine;8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)triinden-1-one, 2,3,9,10,11,12-hexahydro-3-hydroxy-9-methoxy-8-methyl-10-(methylamino)-;UCN 01;UCN 02;UCN-01;UCN-02

Chemical Property of Ucn-01

Chemical Property:

• Vapor Pressure: 6.64E-21mmHg at 25°C
• Boiling Point: 705.7°C at 760 mmHg
• PKA: 12.25±0.70(Predicted)
• Flash Point: 380.6°C
• PSA: 89.68000
• Density: 1.63g/cm³
• LogP: 4.56460
• Solubility.: Soluble in DMSO
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 482.19540532
• Heavy Atom Count: 36
• Complexity: 935

Purity/Quality:

99%+, ^*data from raw suppliers

Antibiotic UCN-02 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)C(NC6=O)O)NC)OC
• Isomeric SMILES: C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)[C@@H](NC6=O)O)NC)OC
• Recent ClinicalTrials: UCN-01 (7-Hydroxystaurosporine) to Treat Relapsed T-Cell Lymphomas
• Description: UCN-02 is a derivative of staurosporine and a stereoisomer of UCN-01 first isolated from a high staurosporine-producing Streptomyces culture as a minor co-metabolite. UCN-02 inhibits protein kinase C with a slightly reduced potency than UCN-01 (IC50 = 62 and 4.1 nM, for UNC-02 and UCN-01, respectively) and is cytotoxic to the growth of HeLa S3 cells.
• Uses: UCN-02 is an indolocarbazole isolated from a high staurosporine-producing Streptomyces culture as a minor co-metabolite. Although less selective than its isomer UCN-01, UCN-02 exhibits comparable activity and probably acts by similar mechanisms. UCN-02 is an antibiotic and an indolocarbazole isolated from a high staurosporine-producing?Streptomyces?culture. Related analogs of staurosporine which is non-specific protein kinase inhibitor.