[2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid

Base Information

• Chemical Name: [2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
• CAS No.: 16142-03-3
• Molecular Formula: C13H26 O8
• Molecular Weight: 310.345
• Mol file: 16142-03-3.mol

Synonyms:2,5,8,11,14,17-Hexaoxanonadecan-19-oicacid (6CI,8CI,9CI); Acetic acid,[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]-;[2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid

Chemical Property of [2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid

Chemical Property:

• PSA: 92.68000
• LogP: -0.19960

Purity/Quality:

99% ^*data from raw suppliers

mPEG5-CH2COOH min.95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: m-PEG6-CH2COOH is a PEG linker containing a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media.

Technology Process of [2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid

There total 6 articles about [2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

→ 2,5,8,11,14,17-hexaoxanonadecan-19-oic acid (16142-03-3)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; for 0.333333h; Cooling with ice;

In tetrahydrofuran; mineral oil; at 20 ℃; for 13h; Cooling with ice;

With water; lithium hydroxide; In tetrahydrofuran; mineral oil; for 4h; Reflux;

Reference yield:

C19H42O7Si → 2,5,8,11,14,17-hexaoxanonadecan-19-oic acid (16142-03-3)

Guidance literature:

With Jones reagent; In acetone; at 0 - 20 ℃; for 17h; Inert atmosphere;

Reference yield:

2-{2-[2-(2-{2-[2-(tert-butyldimethylsilanyloxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethanol (194281-47-5) → 2,5,8,11,14,17-hexaoxanonadecan-19-oic acid (16142-03-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 18 h / 0 - 20 °C / Inert atmosphere

2.1: Jones reagent / acetone / 17 h / 0 - 20 °C / Inert atmosphere

With Jones reagent; sodium hydride; In tetrahydrofuran; acetone; mineral oil;

upstream raw materials:

chloroacetic acid

3,6,9,12,15-pentaoxahexadecanol

bromoacetic acid

2-{2-[2-(2-{2-[2-(tert-butyldimethylsilanyloxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethanol

Refernces

• 1、 -. "CONJUGATES COMPRISING SELF-IMMOLATIVE GROUPS AND METHODS RELATED THERETO". . . Retrieved 2017/06/27.
• 2、 Tuchscherer,Schaarschmidt,Schulze,Hietschold,Lang. "Gold nanoparticles generated by thermolysis of "all-in-one" gold(i) carboxylate complexes". scheme or table. p. 2738 - 2746. Retrieved 2012/04/10.