trimethyl-[(E)-5-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)pent-2-en-3-yl]silane

Base Information

Chemical Name:trimethyl-[(E)-5-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)pent-2-en-3-yl]silane
CAS No.:83665-54-7
Molecular Formula:C₁₉H₂₈N₂Si
Molecular Weight:312.53
Hs Code.:
NSC Number:619165,617623
DSSTox Substance ID:DTXSID50417700
ChEMBL ID:CHEMBL1993727

Synonyms:NSC619165;83665-54-7;NSC617623;MLS002701765;CHEMBL1993727;DTXSID50417700;NSC-617623;NSC-619165;PD011876;1H-Pyrido[3, 2,3,4,9-tetrahydro- 1-[3-(trimethylsilyl)-3-pentenyl]-, (E)-

Suppliers and Price of trimethyl-[(E)-5-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)pent-2-en-3-yl]silane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of trimethyl-[(E)-5-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)pent-2-en-3-yl]silane

Chemical Property:

Vapor Pressure:6.71E-08mmHg at 25°C
Boiling Point:438.8°C at 760 mmHg
Flash Point:219.2°C
Density:1.006g/cm³
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:4
Exact Mass:312.202175436
Heavy Atom Count:22
Complexity:412

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC=C(CCC1C2=C(CCN1)C3=CC=CC=C3N2)[Si](C)(C)C
Isomeric SMILES:C/C=C(\CCC1C2=C(CCN1)C3=CC=CC=C3N2)/[Si](C)(C)C

Technology Process of trimethyl-[(E)-5-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)pent-2-en-3-yl]silane

There total 5 articles about trimethyl-[(E)-5-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)pent-2-en-3-yl]silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6224-91-5
trimethyl(prop-1-ynyl)silane

: 83665-54-7
(E)-2,3,4,9-tetrahydro-1-<3-(trimethylsilyl)-3-pentenyl>-1H-pyrido<3,4-b>indole

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Bu₂AlH, 2.) Br₂, pyridine / 1.) Et₂O, 40 deg C, 2.) -78 deg C to RT

2: 1.) sec-BuLi / 1.) THF, cyclohexane, -78 deg C, 0.5 h, 2.) -78 deg C, 30 min, RT

3: NBS, pyridine / diethyl ether / 2 h / 0 °C / Irradiation

4: 1 N HCl / tetrahydrofuran / 24 h / Ambient temperature

5: methanol; H₂O / 30 h / 85 °C

With pyridine; hydrogenchloride; N-Bromosuccinimide; bromine; sec.-butyllithium; dibutylaluminum hydride; In tetrahydrofuran; methanol; diethyl ether; water;
DOI:10.1021/jo00148a013

Reference yield:

: 65425-88-9
(Z)-1-Bromo-1-(trimethylsilyl)-1-propene

: 83665-54-7
(E)-2,3,4,9-tetrahydro-1-<3-(trimethylsilyl)-3-pentenyl>-1H-pyrido<3,4-b>indole

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) sec-BuLi / 1.) THF, cyclohexane, -78 deg C, 0.5 h, 2.) -78 deg C, 30 min, RT

2: NBS, pyridine / diethyl ether / 2 h / 0 °C / Irradiation

3: 1 N HCl / tetrahydrofuran / 24 h / Ambient temperature

4: methanol; H₂O / 30 h / 85 °C

With pyridine; hydrogenchloride; N-Bromosuccinimide; sec.-butyllithium; In tetrahydrofuran; methanol; diethyl ether; water;
DOI:10.1021/jo00148a013

Reference yield:

: 83665-51-4
(Z)-<1-<3-(ethylenedioxy)-1-propyl>-1-propenyl>trimethylsilane

: 83665-54-7
(E)-2,3,4,9-tetrahydro-1-<3-(trimethylsilyl)-3-pentenyl>-1H-pyrido<3,4-b>indole

Guidance literature:: Multi-step reaction with 3 steps

1: NBS, pyridine / diethyl ether / 2 h / 0 °C / Irradiation

2: 1 N HCl / tetrahydrofuran / 24 h / Ambient temperature

3: methanol; H₂O / 30 h / 85 °C

With pyridine; hydrogenchloride; N-Bromosuccinimide; In tetrahydrofuran; methanol; diethyl ether; water;
DOI:10.1021/jo00148a013