(5Z)-5-(4-Hydroxybenzylidene)-2,4-imidazolidinedione

Base Information

• Chemical Name: (5Z)-5-(4-Hydroxybenzylidene)-2,4-imidazolidinedione
• CAS No.: 80171-33-1
• Molecular Formula: C10H8N2O3
• Molecular Weight: 204.185
• Hs Code.: 2933990090
• NSC Number: 49419
• ChEMBL ID: CHEMBL432684
• Mol file: 80171-33-1.mol

Synonyms:4-hydroxyphenylmethylene hydantoin

Chemical Property of (5Z)-5-(4-Hydroxybenzylidene)-2,4-imidazolidinedione

Chemical Property:

• Melting Point: 316-318℃
• Refractive Index: 1.686
• PSA: 78.43000
• Density: 1.458g/cm³
• LogP: 1.23010
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 204.05349212
• Heavy Atom Count: 15
• Complexity: 317

Purity/Quality:

97% ^*data from raw suppliers

Phenylmethylene hydantoin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C=C2C(=O)NC(=O)N2)O
• Isomeric SMILES: C1=CC(=CC=C1/C=C\2/C(=O)NC(=O)N2)O

Technology Process of (5Z)-5-(4-Hydroxybenzylidene)-2,4-imidazolidinedione

There total 10 articles about (5Z)-5-(4-Hydroxybenzylidene)-2,4-imidazolidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2,4-imidazolidinedione (461-72-3) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 5-(4-hydroxybenzylidene)imidazolidine-2,4-dione (80171-33-1)

Guidance literature:

With piperidine; at 130 ℃; for 0.5h; Reflux;

Reference yield: 78.5%

2,4-imidazolidinedione (461-72-3) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 5-(4'-hydroxybenzylidene)-hydantoin (80171-33-1)

Guidance literature:

With piperidine; for 0.5h; Inert atmosphere; Reflux;

DOI:10.1016/j.bbagen.2011.03.001

Reference yield:

2,4-imidazolidinedione (461-72-3) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 5-(p-hydroxybenzylidene)hydantoin (80171-33-1)

Guidance literature:

With pyridine; diethylamine;

upstream raw materials:

2,4-imidazolidinedione

4-hydroxy-benzaldehyde

(5Z)-5-(4-hydroxybenzylidene)-2-thioxoimidazolidin-4-one

piperidine

Downstream raw materials:

4-hydroxyphenylpiruvic acid

5-(4-hydroxy-benzyl)-imidazolidine-2,4-dione

5-(4-(benzyloxy)benzylidene)imidazolidine-2,4-dione

5-(4-((2-chlorobenzyl)oxy)benzylidene)imidazolidine-2,4-dione