(2R,3R,4aS,4bS,10aS,10bR,11S,12aS)-10b-fluoro-2,3,11-trihydroxy-2,10a,12a-trimethyl-3,4,4a,5,6,10a,10b,11,12,12a-decahydrochrysene-1,8(2H,4bH)-dione

Base Information

Chemical Name:(2R,3R,4aS,4bS,10aS,10bR,11S,12aS)-10b-fluoro-2,3,11-trihydroxy-2,10a,12a-trimethyl-3,4,4a,5,6,10a,10b,11,12,12a-decahydrochrysene-1,8(2H,4bH)-dione
CAS No.:3834-28-4
Molecular Formula:C21H27FO5
Molecular Weight:378.4345
Hs Code.:

(2R,3R,4aS,4bS,10aS,10bR,11S,12aS)-10b-fluoro-2,3,11-trihydroxy-2,10a,12a-trimethyl-3,4,4a,5,6,10a,10b,11,12,12a-decahydrochrysene-1,8(2H,4bH)-dione

Synonyms:

Suppliers and Price of (2R,3R,4aS,4bS,10aS,10bR,11S,12aS)-10b-fluoro-2,3,11-trihydroxy-2,10a,12a-trimethyl-3,4,4a,5,6,10a,10b,11,12,12a-decahydrochrysene-1,8(2H,4bH)-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R,4aS,4bS,10aS,10bR,11S,12aS)-10b-fluoro-2,3,11-trihydroxy-2,10a,12a-trimethyl-3,4,4a,5,6,10a,10b,11,12,12a-decahydrochrysene-1,8(2H,4bH)-dione

Chemical Property:

Vapor Pressure:2.39E-14mmHg at 25°C
Boiling Point:549.2°C at 760 mmHg
Flash Point:285.9°C
Density:1.35g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2R,3R,4aS,4bS,10aS,10bR,11S,12aS)-10b-fluoro-2,3,11-trihydroxy-2,10a,12a-trimethyl-3,4,4a,5,6,10a,10b,11,12,12a-decahydrochrysene-1,8(2H,4bH)-dione

There total 10 articles about (2R,3R,4aS,4bS,10aS,10bR,11S,12aS)-10b-fluoro-2,3,11-trihydroxy-2,10a,12a-trimethyl-3,4,4a,5,6,10a,10b,11,12,12a-decahydrochrysene-1,8(2H,4bH)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2135-13-9
9,11β-epoxy-16α,17-isopropylidenedioxy-9β-pregna-1,4-diene-3,20-dione

: 3834-28-4
9-fluoro-11β,16α,17α-trihydroxy-17β-methyl-D-homo-androsta-1,4-diene-3,17a-dione

Guidance literature:: With tetrahydrofuran; chloroform; hydrogen fluoride;
DOI:10.1021/ja01527a051

Reference yield:

: 21604-24-0
11α-hydroxy-4,16-dien-pregnan-3,20-dione

: 3834-28-4
9-fluoro-11β,16α,17α-trihydroxy-17β-methyl-D-homo-androsta-1,4-diene-3,17a-dione

Guidance literature:: Multi-step reaction with 9 steps

1: KMnO₄

2: hydrochloric acid

3: pyridine

4: acetic acid; sodium acetate

5: oxalic acid diethyl ester; sodium methylate; benzene / Behandeln des nach dem Ansaeuern mit wss. Salzsaeure erhaltenen Reaktionsprudukts mit Kaliumacetat in Methanol und mit Brom in Tetrachlormethan

6: 2,4,6-trimethyl-pyridine

7: aqueous dioxane; N-bromo-acetamide; aqueous perchloric acid

8: ethanol; potassium acetate

9: CHCl₃; THF; HF

With tetrahydrofuran; 1,4-dioxane; pyridine; 2,4,6-trimethyl-pyridine; hydrogenchloride; potassium permanganate; perchloric acid; ethanol; chloroform; hydrogen fluoride; sodium methylate; potassium acetate; sodium acetate; acetic acid; oxalic acid diethyl ester; benzene; N-bromoacetamide;
DOI:10.1021/ja01527a051

Reference yield:

: 25541-96-2
11α,16α,17-trihydroxy-pregn-4-ene-3,20-dione

: 3834-28-4
9-fluoro-11β,16α,17α-trihydroxy-17β-methyl-D-homo-androsta-1,4-diene-3,17a-dione

Guidance literature:: Multi-step reaction with 8 steps

1: hydrochloric acid

2: pyridine

3: acetic acid; sodium acetate

4: oxalic acid diethyl ester; sodium methylate; benzene / Behandeln des nach dem Ansaeuern mit wss. Salzsaeure erhaltenen Reaktionsprudukts mit Kaliumacetat in Methanol und mit Brom in Tetrachlormethan

5: 2,4,6-trimethyl-pyridine

6: aqueous dioxane; N-bromo-acetamide; aqueous perchloric acid

7: ethanol; potassium acetate

8: CHCl₃; THF; HF

With tetrahydrofuran; 1,4-dioxane; pyridine; 2,4,6-trimethyl-pyridine; hydrogenchloride; perchloric acid; ethanol; chloroform; hydrogen fluoride; sodium methylate; potassium acetate; sodium acetate; acetic acid; oxalic acid diethyl ester; benzene; N-bromoacetamide;
DOI:10.1021/ja01527a051