N-[5-tert-butyl-4-({6-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]-2-(1-methylethyl)-4-oxo-3,4-dihydro-2H-pyran-5-yl}sulfanyl)-2-methylphenyl]methanesulfonamide

Base Information

Chemical Name:N-[5-tert-butyl-4-({6-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]-2-(1-methylethyl)-4-oxo-3,4-dihydro-2H-pyran-5-yl}sulfanyl)-2-methylphenyl]methanesulfonamide
CAS No.:263842-52-0
Molecular Formula:C₂₈H₃₇NO₆S₂
Molecular Weight:547.737
Hs Code.:

N-[5-tert-butyl-4-({6-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]-2-(1-methylethyl)-4-oxo-3,4-dihydro-2H-pyran-5-yl}sulfanyl)-2-methylphenyl]methanesulfonamide

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[5-tert-butyl-4-({6-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]-2-(1-methylethyl)-4-oxo-3,4-dihydro-2H-pyran-5-yl}sulfanyl)-2-methylphenyl]methanesulfonamide

Chemical Property:

Vapor Pressure:2.21E-17mmHg at 25°C
Boiling Point:642.4°C at 760 mmHg
Flash Point:342.3°C
Density:1.29g/cm³

Purity/Quality:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-[5-tert-butyl-4-({6-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]-2-(1-methylethyl)-4-oxo-3,4-dihydro-2H-pyran-5-yl}sulfanyl)-2-methylphenyl]methanesulfonamide

There total 3 articles about N-[5-tert-butyl-4-({6-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]-2-(1-methylethyl)-4-oxo-3,4-dihydro-2H-pyran-5-yl}sulfanyl)-2-methylphenyl]methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 207736-87-6
4-hydroxy-6-[2-(4-hydroxy-phenyl)ethyl]-6-isopropyl-5,6-dihydro-pyran-2-one

: 263843-08-9
toluene-4-thiosulfonic acid S-(2-tert-butyl-4-methanesulfonylamino-5-methylphenyl) ester

: 263842-52-0
N-(5-tert-butyl-4-{4-hydroxy-6-[2-(4-hydroxy-phenyl)-ethyl]-6-isopropyl-2-oxo-5,6-dihydro-2H-pyran-3-ylsulfanyl}-2-methyl-phenyl)-methanesulfonamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm990281p

Reference yield:

: 66422-87-5
1-(4-hydroxyphenyl)-4-methylpentan-3-one

: 263842-52-0
N-(5-tert-butyl-4-{4-hydroxy-6-[2-(4-hydroxy-phenyl)-ethyl]-6-isopropyl-2-oxo-5,6-dihydro-2H-pyran-3-ylsulfanyl}-2-methyl-phenyl)-methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

2: 68 percent / K₂CO₃ / dimethylformamide / 20 °C

With potassium carbonate; In N,N-dimethyl-formamide; 2: Substitution;
DOI:10.1021/jm990281p

Reference yield:

: 207737-29-9
toluene-4-thiosulfonic acid S-(4-amino-2-tert-butyl-5-methylphenyl) ester

: 263842-52-0
N-(5-tert-butyl-4-{4-hydroxy-6-[2-(4-hydroxy-phenyl)-ethyl]-6-isopropyl-2-oxo-5,6-dihydro-2H-pyran-3-ylsulfanyl}-2-methyl-phenyl)-methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / pyridine / CH₂Cl₂ / 20 °C

2: 68 percent / K₂CO₃ / dimethylformamide / 20 °C

With pyridine; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide; 1: Sulfonylation / 2: Substitution;
DOI:10.1021/jm990281p