3-phenylpropyl bromoacetate

Base Information

• Chemical Name: 3-phenylpropyl bromoacetate
• CAS No.: 59956-66-0
• Molecular Formula: C11H13BrO2
• Molecular Weight: 257.127
• Mol file: 59956-66-0.mol

Synonyms:

Chemical Property of 3-phenylpropyl bromoacetate

Chemical Property:

• Vapor Pressure: 0.000256mmHg at 25°C
• Boiling Point: 323.8°C at 760 mmHg
• Flash Point: 149.6°C
• Density: 1.364g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-phenylpropyl bromoacetate

There total 2 articles about 3-phenylpropyl bromoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Phenyl-1-propanol (122-97-4) + 2-Bromoacetyl bromide (598-21-0) → 3-phenylpropyl 2-bromoacetate (59956-66-0)

Guidance literature:

With sodium hydrogencarbonate; In acetonitrile; at 0 ℃; for 0.166667h;

DOI:10.1021/ol701432k

Reference yield:

3-Phenyl-1-propanol (122-97-4) + bromoacetic acid (79-08-3) → 3-phenylpropyl 2-bromoacetate (59956-66-0)

Guidance literature:

With toluene-4-sulfonic acid; benzene;

DOI:10.1021/jf60093a005

Reference yield:

3-phenylpropyl 2-bromoacetate (59956-66-0) → 3-cyclohexyl-propionic acid-(3-phenyl-propyl ester) (85204-27-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: toluene / 20 °C

1.2: 20 °C

2.1: tris[2-phenylpyridinato-C²,N]iridium(III); ascorbic acid; pentafluorophenylthiol / water; 1,2-dimethoxyethane / 40 h / 20 °C / Inert atmosphere; Sealed tube; Irradiation

With pentafluorophenylthiol; tris[2-phenylpyridinato-C²,N]iridium(III); ascorbic acid; In 1,2-dimethoxyethane; water; toluene;

DOI:10.1002/anie.201809115

upstream raw materials:

3-Phenyl-1-propanol

bromoacetic acid

2-Bromoacetyl bromide

Downstream raw materials:

(Diisopropoxy-phosphoryl)-acetic acid 3-phenyl-propyl ester

3-phenyl-1-propyl diazoacetate

3'-phenyl-1'-propyl 4-phenylbutyrate

3-phenylpropyl 2-cyclopentylacetate

Refernces

• 1、 Ideue, Eiji,Toma, Tatsuya,Shimokawa, Jun,Fukuyama, Tohru. "Convenient synthesis of α-diazoacetates from α-bromoacetates and n,n'-ditosylhydrazine: Preparation of benzyl diazoacetate". . p. 501 - 509. Retrieved 2014/04/17.