2,8-Quinolinediol

Base Information

• Chemical Name: 2,8-Quinolinediol
• CAS No.: 15450-76-7
• Molecular Formula: C9H7NO2
• Molecular Weight: 161.16
• Hs Code.: 2933499090
• NSC Number: 108383
• UNII: 466PKO4UBM
• DSSTox Substance ID: DTXSID70165650
• Nikkaji Number: J28.252I
• Metabolomics Workbench ID: 51013
• ChEMBL ID: CHEMBL5083704
• Mol file: 15450-76-7.mol

Synonyms:2,8-Quinolinediol(7CI);Carbostyril, 8-hydroxy- (6CI,8CI);2,8-Dihydroxyquinoline;8-Hydroxy-1H-quinolin-2-one;8-Hydroxy-2(1H)-quinolinone;8-Hydroxy-2-oxo-1,2-dihydroquinoline;8-Hydroxycarbostyril;NSC 108383;

Chemical Property of 2,8-Quinolinediol

Chemical Property:

• Appearance/Colour: white to crystalline powder
• Vapor Pressure: 4.46E-07mmHg at 25°C
• Melting Point: -290 °C (dec.)
• Refractive Index: 1.639
• Boiling Point: 403.2 °C at 760 mmHg
• PKA: 8.85±0.20(Predicted)
• Flash Point: 197.6 °C
• PSA: 53.35000
• Density: 1.337 g/cm³
• LogP: 1.64600
• Storage Temp.: Room temperature.
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated)
• XLogP3: 1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 161.047678466
• Heavy Atom Count: 12
• Complexity: 225

Purity/Quality:

98% ^*data from raw suppliers

8-Hydroxy-2(1H)-quinolinone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-36/38
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C(=C1)O)NC(=O)C=C2
• Uses: 2,8-Quinolinediol is a substituted quinolinone derivative used in the preparation of pharmaceutical compounds. 2,8-Quinolinediol is suitable for use as standard in a study to identify the urinary metabolites for the toxicity related processes and pathogenesis induced by doxorubicin (DOX) to rats by online and off-line LC-MS techniques. It may be used as starting reagent for the preparation of two powerful β2-adrenergic receptor agonists, used for the treatment of asthma:ProcaterolIndacaterol

Technology Process of 2,8-Quinolinediol

There total 25 articles about 2,8-Quinolinediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-hydroxyquinolin-8-yl acetate (15450-72-3) → quinoline-2,8-diol (15450-76-7)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 1h;

DOI:10.1139/v05-063

Reference yield: 85.0%

N-(2-methoxyphenyl)-3-phenylacrylamide (6889-84-5) → 8-Hydroxy-1H-quinolin-2-one (15450-76-7)

Guidance literature:

With aluminum (III) chloride; In chlorobenzene; at 110 ℃; for 0.5h; Temperature;

Reference yield: 81.7%

C17H18BNO5 → 8-Hydroxy-1H-quinolin-2-one (15450-76-7)

Guidance literature:

C₁₇H₁₈BNO₅; With aluminum (III) chloride; tris(pentafluorophenyl)borate; at 0 - 90 ℃; for 2h;

With dihydrogen peroxide; acetic acid; at 0 - 20 ℃; for 2h;

upstream raw materials:

8-quinolinol

8-quinolinol-5-sulfonic acid

2-hydroxyquinolin-8-yl acetate

8-Hydroxyquinoline-N-oxide

Downstream raw materials:

2-hydroxyquinolin-8-yl acetate

2-chloroquinolin-8-ol

8-(benzyloxy)quinolin-2-ol

1-[2-(2(1H)-quinolon-8-yloxymethyl)phenyl]heptyl acetate