Chemical Property of Pyroxamide
Chemical Property:
- PSA：91.32000
- Density:1.215 g/cm3
- LogP:2.33000
- Storage Temp.:?20°C
- Solubility.:DMSO: soluble10mg/mL (clear solution)
- XLogP3:0.9
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:8
- Exact Mass:265.14264148
- Heavy Atom Count:19
- Complexity:284
- Purity/Quality:
-
99%, *data from raw suppliers
Pyroxamide *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn
- Statements:
22
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1=CC(=CN=C1)NC(=O)CCCCCCC(=O)NO
- Recent ClinicalTrials:Pyroxamide in Treating Patients With Advanced Cancer
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Description
Pyroxamide is an inhibitor of histone deacetylases (HDACs), including HDAC1 (IC50 = 0.1-0.2 μM). It induces growth suppression and cell death of certain types of cancer cells in culture.
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Uses
Pyroamide is a histone decetylase inhibitor (HDCi), a novel class of anti-neoplastic agent that acts by enhancing acetylation of histones, promoting uncoiling of chromatin and activation of genes imp
licated in the regulation of cell survival such as poliferation, differentiation and apoptosis. Pyroamide is known to potently inhibits affinity purified HDAC1. Also inhibits the growth of tumor cells
in vitro and in vivo. Induces p21/WAF1 expression in tumor cells. Pyroxamide is an inhibitor of histone deacetylases (HDACs), including HDAC1 (IC50 = 0.1-0.2 μM). It induces growth suppression and cell death of certain types of cancer cells in culture. Pyroamide is a histone decetylase inhibitor (HDCi), a novel class of anti-neoplastic agent that acts by enhancing acetylation of histones, promoting uncoiling of chromatin and activation of genes implicated in the regulation of cell survival such as poliferation, differentiation and apoptosis. Pyroamide is known to potently inhibits affinity purified HDAC1. Also inhibits the growth of tumor cells in vitro and in vivo. Induces p21/WAF1 expression in tumor cells.
