Lunacrine

Base Information

Chemical Name:Lunacrine
CAS No.:82-40-6
Molecular Formula:C₁₆H₁₉NO₃
Molecular Weight:273.332
Hs Code.:
UNII:8QKL3E9913
DSSTox Substance ID:DTXSID30878032
Nikkaji Number:J9.326B
Wikidata:Q27107246
Mol file:82-40-6.mol

Synonyms:LUNACRINE;Lunacrin;Lunacrine [MI];(-)-Lunacrine;82-40-6;Lunacrine, (-)-;UNII-8QKL3E9913;8QKL3E9913;FURO(2,3-b)quinolin-4(2H)-one, 3,9-dihydro-8-methoxy-9-methyl-2-(1-methylethyl)-, (2R)-;(2R)-8-methoxy-9-methyl-2-propan-2-yl-2,3-dihydrofuro[2,3-b]quinolin-4-one;CHEBI:6564;DTXSID30878032;Q27107246;(2R)-3,9-Dihydro-8-methoxy-9-methyl-2-(1-methylethyl)furo[2,3-b]quinolin-4(2H)-one

Suppliers and Price of Lunacrine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Lunacrine

Chemical Property:

Vapor Pressure:1.6E-06mmHg at 25°C
Melting Point:117-119°
Refractive Index:1.5500 (estimate)
Boiling Point:397.4°C at 760 mmHg
Flash Point:194.1°C
PSA：40.46000
Density:1.21g/cm³
LogP:2.50660
XLogP3:3.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:273.13649347
Heavy Atom Count:20
Complexity:443

Purity/Quality:

Safty Information:

Pictogram(s):
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MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)C1CC2=C(O1)N(C3=C(C2=O)C=CC=C3OC)C
Isomeric SMILES:CC(C)[C@H]1CC2=C(O1)N(C3=C(C2=O)C=CC=C3OC)C
Description A further alkaloid obtained from the bark of Lunasia costulata Miq., this base belongs to the furoquinolone group of alkaloids. It crystallizes as the monohydrate in colourless needles from AcOET, m.p. 95.5°C, losing H20 at lOOoC to give the anhydrous form with the above melting point. The alkaloid has [α]28D - 58° (EtOH). The following salts have been prepared: the hydrochloride, m.p. l64-5°C; [α]28D - 23° (H20); hydro bromide, m.p. 170-1 DC; hydriodide, m.p. 196-7°C; aurichloride, m.p. l76-7°C; picrate, m.p. 2l3-4°C and the methiodide, m.p. l30-loC (dec.). The last of these, on treatment with moist silver oxide produces an isomer of lunacrine, m.p. 85-6°C, this behaviour resembling that of certain other Rutaceous alkaloids, e.g. Skimmianine (q.v.). The (+)-form oflunacrine has m.p. 119-1200 C; [α]25589 + 66° and [α]25436+ 100°. This form also yields a crystalline perchlorate, m.p. 178-1800 C. The optically inactive form has been prepared as colourless crystals from AcOEt-pentane, m.p. l46-8°C.The alkaloid inhibits peristaltic movement of the isolated intestine. The median lethal dose of the hydrochloride is approximately 78.7 mgm per kilo when injected intravenously in mice. It is also stated to reduce arterial blood pressure in cats.

Technology Process of Lunacrine

There total 1 articles about Lunacrine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: