Chemical Property of Prinomastat
Chemical Property:
- Melting Point:149.8°
- Boiling Point:°Cat760mmHg
- Flash Point:°C
- PSA：146.00000
- Density:1.377g/cm3
- LogP:4.12300
- Storage Temp.:room temp
- Solubility.:H2O: soluble15mg/mL (clear solution)
- XLogP3:1.5
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:8
- Rotatable Bond Count:5
- Exact Mass:423.09226313
- Heavy Atom Count:28
- Complexity:638
- Purity/Quality:
-
97% *data from raw suppliers
Prinomastat *data from reagent suppliers
Safty Information:
- Pictogram(s):
T
- Hazard Codes:T
- Statements:
60-61
- Safety Statements:
53-45
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC1(C(N(CCS1)S(=O)(=O)C2=CC=C(C=C2)OC3=CC=NC=C3)C(=O)NO)C
- Isomeric SMILES:CC1([C@@H](N(CCS1)S(=O)(=O)C2=CC=C(C=C2)OC3=CC=NC=C3)C(=O)NO)C
- Recent ClinicalTrials:Chemotherapy in Treating Patients Who Have Metastatic Prostate Cancer
-
Uses
Treatment of HaCaT-ras A-5RT3 tumor xenografts with Prinomastat (Ag3340) for 6 days strongly reduces tumor invasion and vascularization. Prinomastat is also a broad spectrum MMP inhibitor Prinomastat hydrochloride has been used as an antagonist for metalloproteinases (MMPs) in Crotalus atrox venom samples and mouse embryo cultures. It may be used as a MMP-2 inhibitor in HepG2 cells. Antineoplastic; antiangiogenic; treatment for retinal and subfoveal choroidal neovascularization (matrix metalloproteinase inhibitor).
