Chemical Property of CID 2920
Chemical Property:
- Appearance/Colour:White powder
- Vapor Pressure:7.28E-21mmHg at 25°C
- Melting Point:206 °C
- Refractive Index:1.608
- Boiling Point:705.057 °C at 760 mmHg
- Flash Point:380.205 °C
- PSA：114.46000
- Density:1.309 g/cm3
- LogP:3.41770
- Storage Temp.:−20°C
- XLogP3:3.5
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:2
- Exact Mass:495.22570239
- Heavy Atom Count:36
- Complexity:986
- Purity/Quality:
-
97% *data from raw suppliers
Cytochalasin E *data from reagent suppliers
Safty Information:
- Pictogram(s):
T, 
T+
- Hazard Codes:T+,T
- Statements:
26/27/28-63
- Safety Statements:
28-36/37-45
- MSDS Files:
-
SDS file from LookChem
Useful:
- Chemical Classes:Biological Agents -> Mycotoxins
- Canonical SMILES:CC1CC=CC2C3C(O3)(C(C4C2(C(=O)NC4CC5=CC=CC=C5)OC(=O)OC=CC(C1=O)(C)O)C)C
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Description
The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin E is an epoxide-containing analog of cytochalasin B which potently and selectively inhibits the growth of endothelial cells (IC50 < 1 nM), impairing angiogenesis and tumor growth. This cytochalasin does not inhibit glucose transport or HIV-1 protease activity.
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Uses
Cytochalasin E is one of a family of potent mycotoxins produced by a range of fungi. All members of the class exhibit profound effects on cytoskeletal proteins, resulting in pronounced morphogenic changes in animals and plants. Despite the common mode of action, there is evidence that individual members display diverse selectivity. Specifically, cytochalasin E acts as an angiogenesis inhibitor and, unlike other cytochalasins, does not inhibit glucose transport. Cytochalasin E has been used as:a toxin to study its effects on avocado plantsa component of the incubating medium in feline junctional adhesion molecule 1 (fJAM-1) expression assay an inhibitor of actin polymerization to study its effects on mitochondria uptake by mice endothelial cells Cytochalasin E is a fungal metabolite which has been shown to exhibit antimicrobial and antibacterial effects. Cytochalasin E is a microfilament inhibitor enhancing the low-affinity Fc epsilon receptor (CD23) expression.
