6-METHOXY-M-TOLUENESULFONYL CHLORIDE

Base Information

• Chemical Name: 6-METHOXY-M-TOLUENESULFONYL CHLORIDE
• CAS No.: 88040-86-2
• Molecular Formula: C8H9 Cl O3 S
• Molecular Weight: 220.677
• Hs Code.: 2909309090
• Mol file: 88040-86-2.mol

Synonyms:2-Methoxy-5-methylbenzenesulfonylchloride

Chemical Property of 6-METHOXY-M-TOLUENESULFONYL CHLORIDE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 82 °C
• Boiling Point: 331.325°C at 760 mmHg
• Flash Point: 154.18°C
• PSA: 51.75000
• Density: 1.326g/cm³
• LogP: 3.01190
• Storage Temp.: Keep Cold

Purity/Quality:

98%min ^*data from raw suppliers

2-Methoxy-5-methylbenzene-1-sulfonylChloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,C
• Statements: 34
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Methoxy-5-methylbenzene-1-sulfonyl Chloride is used in preparation of benzenesulfonamide derivatives and analogs as ATP citrate lyase inhibitors.

Technology Process of 6-METHOXY-M-TOLUENESULFONYL CHLORIDE

There total 2 articles about 6-METHOXY-M-TOLUENESULFONYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

p-methylanizole (104-93-8) → 2-methoxy-5-methylbenzene sulfonyl chloride (88040-86-2)

Guidance literature:

With chlorosulfonic acid; at 0 - 23 ℃; for 5.5h;

DOI:10.1021/ja062355+

Reference yield:

→ 2-methoxy-5-methylbenzene sulfonyl chloride (88040-86-2)

Guidance literature:

With phosphorus pentachloride;

Reference yield: 100.0%

7-bromo-2-trimethylsilanyl-benzofuran-5-ylamine (856677-90-2) + 2-methoxy-5-methylbenzene sulfonyl chloride (88040-86-2) → N-(7-bromo-2-trimethylsilanyl-benzofuran-5-yl)-2-methoxy-5-methyl-benzenesulfonamide (856677-91-3)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 2.5h;

upstream raw materials:

p-methylanizole

Downstream raw materials:

4-methoxy-toluene-3-sulfinic acid

4-methoxy-3-(toluene-4-sulfonyl)-toluene

2-methoxy-5-methylbenzenesulfonic acid 3-ethyl-5-hydroxyphenyl ester

2-methoxy-5-methylbenzenesulfonic acid 3-hydroxyphenyl ester

Refernces

• 1、 D?rr, Carolin,Diehl, Erika,Hellmich, Ute A.,Schollmeyer, Dieter,Shimizu, Akihiro,Waldvogel, Siegfried R.,Wesenberg, Lars J.,Yoshida, Jun-ichi,Z?hringer, Till J. B.. "Metal-Free Twofold Electrochemical C?H Amination of Activated Arenes: Application to Medicinally Relevant Precursor Synthesis". supporting information. p. 17574 - 17580. Retrieved 2020/12/07.
• 2、 Guo, Cheng,Qiu, Jun,Zhang, Xumu,Verdugo, Dawn,Larter, Martin L.,Christie, Ray,Kenney, Patrick,Walsh, Patrick J.. "Enantioselective addition of diethylzinc to benzaldehyde catalyzed by chiral titanate complexes with helical ligands". . p. 4145 - 4158. Retrieved 2007/10/03.