3β-(Methylamino)-4,4,14-trimethyl-9,19-cyclo-5α-pregn-17(20)-en-16-one

Base Information

Chemical Name:3β-(Methylamino)-4,4,14-trimethyl-9,19-cyclo-5α-pregn-17(20)-en-16-one
CAS No.:1053-21-0
Molecular Formula:C₂₅H₃₉NO
Molecular Weight:369.591
Hs Code.:
Mol file:1053-21-0.mol

Synonyms:9,19-Cyclo-5a,9b-pregn-17(20)-en-16-one,4,4,14-trimethyl-3b-(methylamino)-, (E)- (8CI); Cyclobuxophyllinine (7CI); 16H,19H-Cyclopropa[9,10]cyclopenta[a]phenanthrene,9,19-cyclopregn-17(20)-en-16-one deriv.; (-)-(E)-Buxenone; (E)-Buxenone; Buxenone; Buxenone M; Cyclobuxophyllinine M

Suppliers and Price of 3β-(Methylamino)-4,4,14-trimethyl-9,19-cyclo-5α-pregn-17(20)-en-16-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 21 raw suppliers

Chemical Property of 3β-(Methylamino)-4,4,14-trimethyl-9,19-cyclo-5α-pregn-17(20)-en-16-one

Chemical Property:

PSA：29.10000
LogP:5.91350

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3β-(Methylamino)-4,4,14-trimethyl-9,19-cyclo-5α-pregn-17(20)-en-16-one

There total 13 articles about 3β-(Methylamino)-4,4,14-trimethyl-9,19-cyclo-5α-pregn-17(20)-en-16-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 31300-52-4
3β-acetoxy-9,19-cyclo-4,4,14α-trimethyl-5α-pregnan-20-one

: 1053-21-0
cyclobuxophyllinine-M

Guidance literature:: Multi-step reaction with 11 steps

1: NaBH₄ / aq. ethanol; CHCl₃ / 7 h / 0 °C

2: pyridine / 1) 0 grad C, 10 min; 2) 10-15 grad C, 30 hr

3: sym-collidine / 3 h / Heating

4: 1) O₂ / 1) methylene blue, sunlight / 1)pyridine, 35 hr; 2) Ac₂O, 30 grad C, 45 min, 60 grad C, 1 hr

5: 86.7 percent / LAH / diethyl ether / 6 h / 0 °C

6: 80 percent / p-toluenesulphonic acid / 0.33 h / 12 °C

7: 80 percent / pyridinium chromate-on-silica gel / CH₂Cl₂; acetic acid / 6 h / Ambient temperature

8: 88.4 percent / p-toluenesulphonic acid / acetic acid; acetic anhydride / 48 h / Ambient temperature

9: 67 percent / NaBH₃CN, 4A molecular sieves / methanol / 80 h / Ambient temperature

10: 1) KOH; 2) MnO₂ / 1) MeOH, reflux, 4 hr; 2) C₆H₆, rt, 12 hr

11: KOH / aq. ethanol / 2 h / Ambient temperature

With 2,4,6-trimethyl-pyridine; manganese(IV) oxide; potassium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; pyridinium chromate-on-silica gel; 4 A molecular sieve; oxygen; sodium cyanoborohydride; methylene blue; toluene-4-sulfonic acid; In pyridine; methanol; diethyl ether; ethanol; dichloromethane; chloroform; acetic anhydride; acetic acid;
DOI:10.1016/S0040-4020(01)92368-3

Reference yield:

: 80680-68-8
3β-hydroxy-9,19-cyclo-4,4,14α-trimethyl-5α-pregn-16-en-20-ol

: 1053-21-0
cyclobuxophyllinine-M

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / p-toluenesulphonic acid / 0.33 h / 12 °C

2: 80 percent / pyridinium chromate-on-silica gel / CH₂Cl₂; acetic acid / 6 h / Ambient temperature

3: 88.4 percent / p-toluenesulphonic acid / acetic acid; acetic anhydride / 48 h / Ambient temperature

4: 67 percent / NaBH₃CN, 4A molecular sieves / methanol / 80 h / Ambient temperature

5: 1) KOH; 2) MnO₂ / 1) MeOH, reflux, 4 hr; 2) C₆H₆, rt, 12 hr

6: KOH / aq. ethanol / 2 h / Ambient temperature

With manganese(IV) oxide; potassium hydroxide; pyridinium chromate-on-silica gel; 4 A molecular sieve; sodium cyanoborohydride; toluene-4-sulfonic acid; In methanol; ethanol; dichloromethane; acetic anhydride; acetic acid;
DOI:10.1016/S0040-4020(01)92368-3

Reference yield:

: 64371-24-0
3β-acetoxy-9,19-cyclo-4,4,14α-trimethyl-5α-pregn-17(20)-ene

: 1053-21-0
cyclobuxophyllinine-M

Guidance literature:: Multi-step reaction with 8 steps

1: 1) O₂ / 1) methylene blue, sunlight / 1)pyridine, 35 hr; 2) Ac₂O, 30 grad C, 45 min, 60 grad C, 1 hr

2: 86.7 percent / LAH / diethyl ether / 6 h / 0 °C

3: 80 percent / p-toluenesulphonic acid / 0.33 h / 12 °C

4: 80 percent / pyridinium chromate-on-silica gel / CH₂Cl₂; acetic acid / 6 h / Ambient temperature

5: 88.4 percent / p-toluenesulphonic acid / acetic acid; acetic anhydride / 48 h / Ambient temperature

6: 67 percent / NaBH₃CN, 4A molecular sieves / methanol / 80 h / Ambient temperature

7: 1) KOH; 2) MnO₂ / 1) MeOH, reflux, 4 hr; 2) C₆H₆, rt, 12 hr

8: KOH / aq. ethanol / 2 h / Ambient temperature

With manganese(IV) oxide; potassium hydroxide; lithium aluminium tetrahydride; pyridinium chromate-on-silica gel; 4 A molecular sieve; oxygen; sodium cyanoborohydride; methylene blue; toluene-4-sulfonic acid; In methanol; diethyl ether; ethanol; dichloromethane; acetic anhydride; acetic acid;
DOI:10.1016/S0040-4020(01)92368-3