2-methyl-3-[2-(trifluoromethyl)phenyl]quinazolin-4(3H)-one

Base Information

• Chemical Name: 2-methyl-3-[2-(trifluoromethyl)phenyl]quinazolin-4(3H)-one
• CAS No.: 340-49-8
• Molecular Formula: C16H11F3N2O
• Molecular Weight: 304.2665

Synonyms:

Chemical Property of 2-methyl-3-[2-(trifluoromethyl)phenyl]quinazolin-4(3H)-one

Chemical Property:

• Vapor Pressure: 1.14E-06mmHg at 25°C
• Boiling Point: 401.9°C at 760 mmHg
• Flash Point: 196.8°C
• Density: 1.31g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-methyl-3-[2-(trifluoromethyl)phenyl]quinazolin-4(3H)-one

There total 5 articles about 2-methyl-3-[2-(trifluoromethyl)phenyl]quinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

3-[2-(trifluoromethyl)phenyl]-4(3H)-quinazolinone → 3-[2-(trifluoromethyl)phenyl]-2-methylquinazolin-4(3H)-one (340-49-8)

Guidance literature:

With p-toluenesulfonic acid monohydrate; oxygen; at 110 ℃; Sealed tube; Green chemistry;

DOI:10.1039/d0gc01183e

Reference yield: 45.0%

→ 3-[2-(trifluoromethyl)phenyl]-2-methylquinazolin-4(3H)-one (340-49-8)

Guidance literature:

Reference yield:

2-amino-N-[2-(trifluoromethyl)phenyl]benzamide (735-28-4) → 3-[2-(trifluoromethyl)phenyl]-2-methylquinazolin-4(3H)-one (340-49-8)

Guidance literature:

Multi-step reaction with 2 steps

1: oxygen; p-toluenesulfonic acid monohydrate / water / 110 °C / Sealed tube; Green chemistry

2: oxygen; p-toluenesulfonic acid monohydrate / 110 °C / Sealed tube; Green chemistry

With p-toluenesulfonic acid monohydrate; oxygen; In water;

DOI:10.1039/d0gc01183e

upstream raw materials:

2-methyl-4-oxo-3,1-benzoxazine

2-(trifluoromethyl)benzenamine

anthranilic acid

2-amino-N-[2-(trifluoromethyl)phenyl]benzamide

Refernces

Convenient synthesis of bis(3-indolyl)-acetylene via Sonogashira coupling

10.1080/00397910601133631

The study presents a convenient synthesis method for bis(3-indolyl)acetylene, a potentially important class of molecules for heterocycle synthesis. The process involves a Pd-catalyzed cross-coupling reaction of iodoindole and 3-indolylacetylene, followed by deprotection to yield the final product. Key chemicals used include iodoindole, 3-indolylacetylene, Pd(PPh3)4 as a catalyst, and CuI as a co-catalyst. These chemicals serve to facilitate the coupling reaction and protect the intermediate products, ultimately leading to the synthesis of phenylsulfonyl-protected and unprotected bis(3-indolyl)acetylenes. The study also discusses the ongoing chemistry of these internal alkynes in the laboratory, indicating further research in this area.

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