Tiropramide

Base Information

• Chemical Name: Tiropramide
• CAS No.: 55837-29-1
• Molecular Formula: C28H41 N3 O3
• Molecular Weight: 467.652
• UNII: R7S0904CN2
• DSSTox Substance ID: DTXSID70866514
• Wikipedia: Tiropramide
• Wikidata: Q7809264
• NCI Thesaurus Code: C152660
• Metabolomics Workbench ID: 49712
• ChEMBL ID: CHEMBL2104688
• Mol file: 55837-29-1.mol

Synonyms:CR 605;tiropramide

Chemical Property of Tiropramide

Chemical Property:

• Vapor Pressure: 4.94E-17mmHg at 25°C
• Melting Point: 65-67°
• Refractive Index: 1.7800 (estimate)
• Boiling Point: 655°C at 760 mmHg
• PKA: 13.53±0.46(Predicted)
• Flash Point: 349.9°C
• PSA: 61.88000
• Density: 1.06g/cm³
• LogP: 4.78780
• XLogP3: 5.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 15
• Exact Mass: 467.31479218
• Heavy Atom Count: 34
• Complexity: 561

Purity/Quality:

98%Min ^*data from raw suppliers

TIROPRAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCN(CCC)C(=O)C(CC1=CC=C(C=C1)OCCN(CC)CC)NC(=O)C2=CC=CC=C2

Technology Process of Tiropramide

There total 5 articles about Tiropramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-benzoyl-O-benzoyl-L-tyrosine (14325-35-0) → Alfospas (55837-29-1)

Guidance literature:

Multi-step reaction with 3 steps

1: (i) Et₃N, ClCO₂Et, (ii) /BRN= 505974/

2: sodium hydroxide

3: sodium methylate

With sodium hydroxide; sodium methylate;

Reference yield:

O.N-Dibenzoyl-DL-tyrosyl-di-n-propylamid (57227-08-4) → Alfospas (55837-29-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide

2: sodium methylate

With sodium hydroxide; sodium methylate;

Reference yield:

L-tyrosine (60-18-4,18875-48-4,25619-78-7,30704-25-7) → Alfospas (55837-29-1)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydroxide

2: (i) Et₃N, ClCO₂Et, (ii) /BRN= 505974/

3: sodium hydroxide

4: sodium methylate

With sodium hydroxide; sodium methylate;

upstream raw materials:

N-benzoyl-DL-tyrosil-di-n-propylamide

2-(diethylamino)ethyl chloride

N-benzoyl-O-benzoyl-L-tyrosine

O_.N-Dibenzoyl-DL-tyrosyl-di-n-propylamid