Technology Process of 3,5-Difluoroquinoline
There total 3 articles about 3,5-Difluoroquinoline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-amino-3-fluoroquinoline;
With
sodium nitrate; tetrafluoroboric acid;
In
water;
at 0 ℃;
for 1h;
In
toluene;
at 110 ℃;
for 1h;
DOI:10.1021/jm1000908
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 38 percent / 61 percent HNO3; H2SO4 / 5 h / 20 °C
2.1: H2 / 5 percent Pd/C / benzene
3.1: isoamyl nitrite; 42 percent HBF4 / ethanol / 2 h / 0 °C
3.2: xylene / 3 h / Heating
With
tetrafluoroboric acid; sulfuric acid; hydrogen; nitric acid; isopentyl nitrite;
palladium on activated charcoal;
In
ethanol; benzene;
1.1: Nitration / 2.1: Reduction / 3.1: Schiemann reaction / 3.2: Deazotization;
DOI:10.1248/bpb.20.646
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: H2 / 5 percent Pd/C / benzene
2.1: isoamyl nitrite; 42 percent HBF4 / ethanol / 2 h / 0 °C
2.2: xylene / 3 h / Heating
With
tetrafluoroboric acid; hydrogen; isopentyl nitrite;
palladium on activated charcoal;
In
ethanol; benzene;
1.1: Reduction / 2.1: Schiemann reaction / 2.2: Deazotization;
DOI:10.1248/bpb.20.646
