FI 302

Base Information

• Chemical Name: FI 302
• CAS No.: 73356-67-9
• Molecular Formula: C₂₁H₂₄F₃N₃O₂
• Molecular Weight: 407.436
• Mol file: 73356-67-9.mol

Synonyms:FI 302

Chemical Property of FI 302

Chemical Property:

• Vapor Pressure: 5.25E-11mmHg at 25°C
• Boiling Point: 522.3°C at 760 mmHg
• Flash Point: 269.7°C
• PSA: 143.35000
• Density: 1.35g/cm³
• LogP: 4.83660

Purity/Quality:

FI-302 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FI 302

There total 10 articles about FI 302 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-(3-aminopropyl)piperidine (3529-08-6) + 6-trifluoromethyl-4-methyl-furo[3,2-b]indole-2-carbonyl chloride (80019-62-1) → N-(3-piperidinopropyl)-4-methyl-6-trifluoromethyl furo<3,2-b>indole-2-carboxamide (73356-67-9)

Guidance literature:

In benzene; for 1h; Ambient temperature;

DOI:10.1248/cpb.32.4271

Reference yield:

2-furanoic acid (88-14-2) → N-(3-piperidinopropyl)-4-methyl-6-trifluoromethyl furo<3,2-b>indole-2-carboxamide (73356-67-9)

Guidance literature:

Multi-step reaction with 9 steps

1: 1.) 6 N HCl, NaNO₂; 2.) CuCl₂ / 1.) H₂O, -5 deg C, 1 h; 2.) H₂O, 50-55 deg C

2: 89 percent / conc. H₂SO₄ / 7 h / Heating

3: 83 percent / hydrogen / 10percent Pd-C / acetic acid / Ambient temperature

4: 1.) 6 N HCl, NaNO₂; 2.) NaN₃ / 1.) -5 deg C, 1 h; 2.) H₂O, r.t.

5: 70 percent / o-dichlorobenzene / 1 h / 160 - 170 °C

6: 1.) NaH / 1.) dimethylformamide, 1 h, r.t.; 2.) dimethylformamide, 2 h, r.t.

7: 88 percent / 10percent aq. NaOH / ethanol / 1 h / Heating

8: 71 percent / SOCl₂ / benzene / 0.5 h / Heating

9: 89 percent / benzene / 1 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; thionyl chloride; sodium azide; sulfuric acid; hydrogen; sodium hydride; 1,2-dichloro-benzene; copper dichloride; sodium nitrite; palladium on activated charcoal; In ethanol; acetic acid; benzene;

DOI:10.1248/cpb.32.4271

Reference yield:

5-<2-nitro-4-(trifluoromethyl)phenyl>-2-furancarboxylic acid (95611-89-5) → N-(3-piperidinopropyl)-4-methyl-6-trifluoromethyl furo<3,2-b>indole-2-carboxamide (73356-67-9)

Guidance literature:

Multi-step reaction with 8 steps

1: 89 percent / conc. H₂SO₄ / 7 h / Heating

2: 83 percent / hydrogen / 10percent Pd-C / acetic acid / Ambient temperature

3: 1.) 6 N HCl, NaNO₂; 2.) NaN₃ / 1.) -5 deg C, 1 h; 2.) H₂O, r.t.

4: 70 percent / o-dichlorobenzene / 1 h / 160 - 170 °C

5: 1.) NaH / 1.) dimethylformamide, 1 h, r.t.; 2.) dimethylformamide, 2 h, r.t.

6: 88 percent / 10percent aq. NaOH / ethanol / 1 h / Heating

7: 71 percent / SOCl₂ / benzene / 0.5 h / Heating

8: 89 percent / benzene / 1 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; thionyl chloride; sodium azide; sulfuric acid; hydrogen; sodium hydride; 1,2-dichloro-benzene; sodium nitrite; palladium on activated charcoal; In ethanol; acetic acid; benzene;

DOI:10.1248/cpb.32.4271

upstream raw materials:

1-(3-aminopropyl)piperidine

6-trifluoromethyl-4-methyl-furo[3,2-b]indole-2-carbonyl chloride

2-furanoic acid

4-Methyl-6-trifluoromethyl-4H-furo[3,2-b]indole-2-carboxylic acid