1,1-Bis(2-bromoethyl)-cyclohexane

Base Information

• Chemical Name: 1,1-Bis(2-bromoethyl)-cyclohexane
• CAS No.: 3187-34-6
• Molecular Formula: C10H18 Br2
• Molecular Weight: 298.0579
• Mol file: 3187-34-6.mol

Synonyms:NSC 211497

Chemical Property of 1,1-Bis(2-bromoethyl)-cyclohexane

Chemical Property:

• Vapor Pressure: 0.00167mmHg at 25°C
• Boiling Point: 303.4°Cat760mmHg
• Flash Point: 157.7°C
• PSA: 0.00000
• Density: 1.444g/cm³
• LogP: 4.50690

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,1-Bis(2-bromoethyl)-cyclohexane

There total 4 articles about 1,1-Bis(2-bromoethyl)-cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2,2'-(cyclohexane-1,1-diyl)bis(ethan-1-ol) (3187-27-7) → 1,1-bis-(2-bromo-ethyl)-cyclohexane (3187-34-6)

Guidance literature:

With hydrogen bromide; In sulfuric acid; for 20h; Heating;

Reference yield:

1,1-cyclohexanediacetic acid (4355-11-7) → 1,1-bis-(2-bromo-ethyl)-cyclohexane (3187-34-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / LiAlH₄ / diethyl ether; tetrahydrofuran / 1) 2 h, reflux, 2) 12 h, r.t.

2: 71 percent / 47percent aq. HBr / H₂SO₄ / 20 h / Heating

With lithium aluminium tetrahydride; hydrogen bromide; In tetrahydrofuran; diethyl ether; sulfuric acid;

Reference yield:

cyclohexylidenedi-acetic acid diethyl ester (108667-25-0) → 1,1-bis-(2-bromo-ethyl)-cyclohexane (3187-34-6)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄

2: aq. HBr, H₂SO₄

With lithium aluminium tetrahydride; sulfuric acid; hydrogen bromide;

upstream raw materials:

2,2'-(cyclohexane-1,1-diyl)bis(ethan-1-ol)

1,1-cyclohexanediacetic acid

cyclohexylidenedi-acetic acid diethyl ester

Downstream raw materials:

1,1-bis-[2-(4-nitro-phenoxy)-ethyl]-cyclohexane

1,1-Divinylcyclohexan

1,1-bis-[2-(4-amino-phenoxy)-ethyl]-cyclohexane

spiro[5.5]undecane-3-carboxylic acid

Refernces

• 1、 Eilbracht, Peter,Acker, Michael,Totzauer, Walter. "Alkylsubstituted Cyclopentanones via Hydrocarbonylating Cyclization of 1,4-Pentadiene Systems Mediated by Metal Carbonyls". . p. 238 - 242. Retrieved 2007/10/02.