8-Chloro-10-[3-(methylamino)propyl]-10h-phenothiazin-3-ol

Base Information

Chemical Name:8-Chloro-10-[3-(methylamino)propyl]-10h-phenothiazin-3-ol
CAS No.:3546-08-5
Molecular Formula:C16H17ClN2OS
Molecular Weight:0
Hs Code.:
UNII:BDS415V3UI
DSSTox Substance ID:DTXSID30956869
Nikkaji Number:J21.634H
Wikidata:Q27216234
Mol file:3546-08-5.mol

Synonyms:7-Hydroxynorchlorpromazine;3546-08-5;BRN 1086272;BDS415V3UI;7-Hydroxy-nor1-chlorpromazine;7-Hydroxydemethylchlorpromazine;8-chloro-10-[3-(methylamino)propyl]-10h-phenothiazin-3-ol;10H-Phenothiazin-3-ol, 8-chloro-10-(3-(methylamino)propyl)-;Phenothiazine, 2-chloro-10-(3-(dimethylamino)propyl)-7-hydroxy-nor1-;8-CHLORO-10-(3-(METHYLAMINO)PROPYL)-10H-PHENOTHIAZIN-3-OL;UNII-BDS415V3UI;7-OH-NOR1-CPZ;SCHEMBL2738815;DTXSID30956869;CHEBI:125622;LS-105371;8-chloro-10-[3-(methylamino)propyl]-3-phenothiazinol;BRD-K71339761-001-01-8;Q27216234;Phenothiazin-3-ol, 8-chloro-10-(3-(methylamino)propyl)-;2-Chloro-10-[3-(methylamino)propyl]-10H-phenothiazin-7-ol;Phenothiazin-3-ol, 8-chloro-10-(3-(methylamino)propyl)- (7CI,8CI)

Suppliers and Price of 8-Chloro-10-[3-(methylamino)propyl]-10h-phenothiazin-3-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 8-Chloro-10-[3-(methylamino)propyl]-10h-phenothiazin-3-ol

Chemical Property:

Vapor Pressure:1.62E-11mmHg at 25°C
Boiling Point:522°C at 760 mmHg
Flash Point:269.5°C
PSA：60.80000
Density:1.302g/cm³
LogP:4.71370
XLogP3:4.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:320.0750120
Heavy Atom Count:21
Complexity:346

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNCCCN1C2=C(C=C(C=C2)O)SC3=C1C=C(C=C3)Cl

Technology Process of 8-Chloro-10-[3-(methylamino)propyl]-10h-phenothiazin-3-ol

There total 3 articles about 8-Chloro-10-[3-(methylamino)propyl]-10h-phenothiazin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14734-81-7
[3-(2-chloro-7-isopropoxy-phenothiazin-10-yl)-propyl]-methyl-amine

: 3546-08-5
10-(3-Methylamino-propyl)-7-hydroxy-2-chlor-phenthiazin

Guidance literature:: With hydrogenchloride; at 105 ℃; for 1h;

Reference yield:

: 2002-32-6
8-chloro-10H-phenothiazin-3-ol

: 3546-08-5
10-(3-Methylamino-propyl)-7-hydroxy-2-chlor-phenthiazin

Guidance literature:: Multi-step reaction with 3 steps

1: Na₂S₂O₄, KOH / ethanol / 8 h / Heating

2: (i) NaH, DMSO, (ii) /BRN= 1098733/, (iii) aq. NaOH, EtOH

3: aq. HCl / 1 h / 105 °C

With hydrogenchloride; potassium hydroxide; sodium dithionite; In ethanol;

Reference yield:

: 14782-61-7
2-chloro-7-isopropoxy-10H-phenothiazine

: 3546-08-5
10-(3-Methylamino-propyl)-7-hydroxy-2-chlor-phenthiazin

Guidance literature:: Multi-step reaction with 2 steps

1: (i) NaH, DMSO, (ii) /BRN= 1098733/, (iii) aq. NaOH, EtOH

2: aq. HCl / 1 h / 105 °C

With hydrogenchloride;