N-(cyclopropylmethyl)-6,14-endo-etheno-7-(3-carboxy-3-n-butenyl)tetrahydronororipavine gamma-lactone

Base Information

Chemical Name:N-(cyclopropylmethyl)-6,14-endo-etheno-7-(3-carboxy-3-n-butenyl)tetrahydronororipavine gamma-lactone
CAS No.:127154-03-4
Molecular Formula:C₂₈H₃₁NO₅
Molecular Weight:461.558
Hs Code.:
Mol file:127154-03-4.mol

Synonyms:6,14-Ethenomorphinan,2(3H)-furanone deriv.

Suppliers and Price of N-(cyclopropylmethyl)-6,14-endo-etheno-7-(3-carboxy-3-n-butenyl)tetrahydronororipavine gamma-lactone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of N-(cyclopropylmethyl)-6,14-endo-etheno-7-(3-carboxy-3-n-butenyl)tetrahydronororipavine gamma-lactone

Chemical Property:

PSA：68.23000
Density:1.41g/cm³
LogP:3.20230

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-(cyclopropylmethyl)-6,14-endo-etheno-7-(3-carboxy-3-n-butenyl)tetrahydronororipavine gamma-lactone

There total 7 articles about N-(cyclopropylmethyl)-6,14-endo-etheno-7-(3-carboxy-3-n-butenyl)tetrahydronororipavine gamma-lactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 127131-25-3
3-O-(tert-butyldimethylsilyl)-N-(cyclopropylmethyl)-6,14-endo-etheno-7α-(3-carboxy-3-n-butenyl)tetrahydronororipavine γ-lactone

: 127154-03-4
N-(cyclopropylmethyl)-6,14-endo-etheno-7α-(3-carboxy-3-n-butenyl)tetrahydronororipavine γ-lactone

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 1.16667h;
DOI:10.1021/jm00170a038

Reference yield:

: 127131-20-8
norheterocodeine

: 127154-03-4
N-(cyclopropylmethyl)-6,14-endo-etheno-7α-(3-carboxy-3-n-butenyl)tetrahydronororipavine γ-lactone

Guidance literature:: Multi-step reaction with 6 steps

1: 78 percent / NaHCO₃ / dimethylformamide / 7 h / 90 °C

2: 97 percent / imidazole / dimethylformamide / 22 h

3: 22 percent / γ-MnO2 / tetrahydrofuran / 20 h

4: 84 percent / benzene / 3 h / 50 °C

5: 65 percent / activated zinc / tetrahydrofuran / 6 h / 50 °C

6: 80 percent / n-Bu₄NF / tetrahydrofuran / 1.17 h

With 1H-imidazole; manganese(IV) oxide; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; zinc; In tetrahydrofuran; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00170a038

Reference yield:

: 127131-21-9
N-(cyclopropylmethyl)norheterocodeine

: 127154-03-4
N-(cyclopropylmethyl)-6,14-endo-etheno-7α-(3-carboxy-3-n-butenyl)tetrahydronororipavine γ-lactone

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / imidazole / dimethylformamide / 22 h

2: 22 percent / γ-MnO2 / tetrahydrofuran / 20 h

3: 84 percent / benzene / 3 h / 50 °C

4: 65 percent / activated zinc / tetrahydrofuran / 6 h / 50 °C

5: 80 percent / n-Bu₄NF / tetrahydrofuran / 1.17 h

With 1H-imidazole; manganese(IV) oxide; tetrabutyl ammonium fluoride; zinc; In tetrahydrofuran; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00170a038