METRIFUDIL

Base Information

• Chemical Name: METRIFUDIL
• CAS No.: 23707-33-7
• Molecular Formula: C18H21 N5 O4
• Molecular Weight: 371.396
• Mol file: 23707-33-7.mol

Synonyms:Adenosine,N-(o-methylbenzyl)- (8CI); Metrifudil; N6-(2-Methylbenzyl)adenosine;N6-(o-Methylbenzyl)adenosine; Th 332; Y 341

Chemical Property of METRIFUDIL

Chemical Property:

• Vapor Pressure: 3.15E-20mmHg at 25°C
• Boiling Point: 694.1°C at 760 mmHg
• Flash Point: 373.6°C
• PSA: 125.55000
• Density: 1.57g/cm³
• LogP: 0.43130
• Storage Temp.: −20°C
• Solubility.: H2O: 0.3 mg/mL

Purity/Quality:

97% ^*data from raw suppliers

Metrifudil ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Metrifudil is a N6-substituted adenosine derivative that is potent and selective A3 adenosine receptor agonist.

Technology Process of METRIFUDIL

There total 3 articles about METRIFUDIL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

ortho-methylbenzylamine (89-93-0) + 6-Chloropurine riboside (2004-06-0) → metrifudil (23707-33-7)

Guidance literature:

N-ethyl-N,N-diisopropylamine; In 1,4-dioxane;

Reference yield:

→ (2R,3R,4S,5R)-2-(6-(azepan-1-yl)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (43139-02-2) + metrifudil (23707-33-7)

Guidance literature:

Reference yield:

→ metrifudil (23707-33-7)

Guidance literature:

upstream raw materials:

ortho-methylbenzylamine

6-Chloropurine riboside

Refernces

• 1、 -. "SUBSTITUTION DERIVATIVES OF N6-BENZYLADENOSINE, METHODS OF THEIR PREPARATION, THEIR USE FOR PREPARATION OF DRUGS, COSMETIC PREPARATIONS AND GROWTH REGULATORS, PHARMACEUTICAL PREPARATIONS, COSMETIC PREPARATIONS AND GROWTH REGULATORS CONTAINING THESE COMPOU". Page 42. . Retrieved 2008/06/13.
• 2、 Bressi,Choe,HoughHough,Buckner,Van Voorhis,Verlinde,Hol,Gelb. "Adenosine analogues as inhibitors of Trypanosoma brucei phosphoglycerate kinase: Elucidation of a novel binding mode for a 2-Amino-N6-substituted adenosine". . p. 4135 - 4150. Retrieved 2007/10/03.