Chemical Property of Biotin hydrazide
Chemical Property:
- Appearance/Colour:white or slightly yellow powder
- Vapor Pressure:6.21E-16mmHg at 25°C
- Melting Point:245-247 °C
- Refractive Index:1.553
- Boiling Point:633.1 °C at 760 mmHg
- PKA:13.25±0.35(Predicted)
- Flash Point:336.7 °C
- PSA：121.55000
- Density:1.243 g/cm3
- LogP:1.45090
- Storage Temp.:2-8°C
- Solubility.:DMSO: ≤20 mg/mL
- XLogP3:-0.7
- Hydrogen Bond Donor Count:4
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:5
- Exact Mass:258.11504700
- Heavy Atom Count:17
- Complexity:313
- Purity/Quality:
-
97% *data from raw suppliers
Biotin hydrazide *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Safety Statements:
24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1C2C(C(S1)CCCCC(=O)NN)NC(=O)N2
- Isomeric SMILES:C1[C@H]2[C@@H]([C@@H](S1)CCCCC(=O)NN)NC(=O)N2
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Description
Biotin hydrazide is a biotinyl derivative used to label surface functional groups, antibodies, lectins, sugars, nucleic acids, or molecules with free carboxylic or keto groups. Biotin hydrazide is used as a probe for determining protein carbonylation, an irreversible posttranslational modification resulting from the actions of reactive oxygen species or lipid oxidation products. The reaction of this probe is direct and does not require catalysts or reducing agents.
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Uses
aldehyde reactive biotinylation reagent (+)-Biotin hydrazide has been used:the modification of alginatefor the labelling of mitochondrial proteins from non-muscle tissues as a component of glycoprotein staining solutionin periodic acid-biotin-hydrazide (PABH) assay for mucinsfor labeling surface functional groups, biologically active molecules such as antibodies, lectins, sugars, nucleic acids or molecules with free carboxylic or keto groups.for coupling to glycoproteins through the carbohydrate by hydrazone formation Biotin Hydrazide is a carbohydrate reactive biotinylation reagent used predominately for labeling monoclonal antibodies, unpaired cytosine residues in nucleic acids and glycoproteins.
