(-)-7-OCTYLINDOLACTAM V

Base Information

• Chemical Name: (-)-7-OCTYLINDOLACTAM V
• CAS No.: 109346-66-9
• Molecular Formula: C₂₅H₃₉N₃O₂
• Molecular Weight: 413.604
• Mol file: 109346-66-9.mol

Synonyms:3H-Pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one,1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-9-octyl-,[2S-(2R*,5R*)]-; (-)-7-Octylindolactam V; 7-Octylindolactam V

Chemical Property of (-)-7-OCTYLINDOLACTAM V

Chemical Property:

• Vapor Pressure: 9.41E-18mmHg at 25°C
• Boiling Point: 649.4°Cat760mmHg
• Flash Point: 346.6°C
• PSA: 68.36000
• Density: 1.059g/cm³
• LogP: 4.95870
• Storage Temp.: −20°C

Purity/Quality:

99.3% ^*data from raw suppliers

(-)-7-OCTYLINDOLACTAM V 95.00% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (-)-7-OCTYLINDOLACTAM V

There total 17 articles about (-)-7-OCTYLINDOLACTAM V which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(10S,13S)-10-Isopropyl-9-methyl-5-octyl-11-oxo-3,9,12-triaza-tricyclo[6.6.1.04,15]pentadeca-1,4(15),5,7-tetraene-13-carboxylic acid ethyl ester (160169-46-0) → (-)-7-octylindolactam V (109346-66-9)

Guidance literature:

With lithium borohydride; In tetrahydrofuran;

DOI:10.1016/S0040-4039(00)78434-6

Reference yield: 41.5%

(-)-7-n-octyl-14-O-TBDMS-indolactam-V (214267-85-3) → (-)-7-octylindolactam V (109346-66-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; Ambient temperature;

DOI:10.1271/bbb.62.1568

Reference yield:

indolactam V (84590-48-7,84622-58-2,90365-54-1,90365-55-2,90365-56-3,132341-58-3,90365-57-4) → (-)-7-octylindolactam V (109346-66-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 99.7 percent / imidazole / dimethylformamide / Ambient temperature

2: 40.3 percent / NBS / dimethylformamide / 1.5 h / 0 °C

3: 38.8 percent / Pd(OAc)2, tri-o-tolylphosphine, Et₃N / acetonitrile / Heating

4: 63.8 percent / H₂ / Pd/C / ethanol / Ambient temperature

5: 41.5 percent / aq. HCl / dioxane / Ambient temperature

With 1H-imidazole; hydrogenchloride; palladium diacetate; N-Bromosuccinimide; hydrogen; triethylamine; tris-(o-tolyl)phosphine; palladium on activated charcoal; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1271/bbb.62.1568

upstream raw materials:

(10S,13S)-10-Isopropyl-9-methyl-5-octyl-11-oxo-3,9,12-triaza-tricyclo[6.6.1.0^4,15]pentadeca-1,4⁽¹⁵⁾,5,7-tetraene-13-carboxylic acid ethyl ester

(-)-7-n-octyl-14-O-TBDMS-indolactam-V

indolactam V

(-)-14-O-TBDMS-indolactam-V