4-Hydroxynipecotic acid

Base Information

Chemical Name:4-Hydroxynipecotic acid
CAS No.:71609-37-5
Molecular Formula:C₆H₁₁NO₃
Molecular Weight:145.158
Hs Code.:
DSSTox Substance ID:DTXSID40992172
Nikkaji Number:J670.421B
Wikidata:Q82982214
Mol file:71609-37-5.mol

Synonyms:4-hydroxy-3-piperidinecarboxylic acid;4-hydroxynipecotic acid;4-hydroxynipecotic acid, cis(+-)-isomer

Suppliers and Price of 4-Hydroxynipecotic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
CIS-4-HYDROXYNIPECOTIC ACID 95.00%
5MG
$ 504.00

Total 11 raw suppliers

Chemical Property of 4-Hydroxynipecotic acid

Chemical Property:

Vapor Pressure:3.72E-06mmHg at 25°C
Boiling Point:346°C at 760 mmHg
PKA:3.57±0.40(Predicted)
Flash Point:163°C
PSA：69.56000
Density:1.299g/cm³
LogP:-0.62980
XLogP3:-2.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:145.07389321
Heavy Atom Count:10
Complexity:137

Purity/Quality:

99% ^*data from raw suppliers

CIS-4-HYDROXYNIPECOTIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CNCC(C1O)C(=O)O
Isomeric SMILES:C1CNC[C@H]([C@H]1O)C(=O)O
Use Description 4-Hydroxynipecotic acid has several applications in different fields. In the pharmaceutical industry, it is used as a precursor in the synthesis of various drugs, particularly those involved in the treatment of neurological and psychiatric disorders. Its unique chemical structure makes it valuable in the development of medications that target neurotransmitter systems and influence brain function. Additionally, in the field of organic chemistry, 4-hydroxynipecotic acid can serve as a building block for the creation of complex organic molecules, contributing to advancements in synthetic chemistry and drug discovery. However, its precise role may vary depending on specific research or industrial requirements within each field, highlighting its potential versatility and importance in various scientific endeavors.

Technology Process of 4-Hydroxynipecotic acid

There total 3 articles about 4-Hydroxynipecotic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: (3RS,4SR)-ethyl 1-(ethoxycarbonyl)-4-hydroxypiperidine-3-carboxylate

: 68464-00-6,71609-37-5,82817-56-9,126150-99-0
(3RS,4SR)-4-hydroxypiperidine-3-carboxylic acid

Guidance literature:: With hydrogenchloride; for 2h; Heating;
DOI:10.1021/jm00352a012

Reference yield:

: 53601-94-8
4-oxo-piperidine-1,3-dicarboxylic acid diethyl ester

: 68464-00-6,71609-37-5,82817-56-9,126150-99-0
(3RS,4SR)-4-hydroxypiperidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / NaBH₄ / ethanol / 3 h / Ambient temperature

2: 60 percent / 5M HCl / 2 h / Heating

With hydrogenchloride; sodium tetrahydroborate; In ethanol;
DOI:10.1021/jm00352a012