1-(4-Methylphenacyl)-2-methyl-5-methoxyindol-3-ylacetic acid

Base Information

• Chemical Name: 1-(4-Methylphenacyl)-2-methyl-5-methoxyindol-3-ylacetic acid
• CAS No.: 106287-91-6
• Molecular Formula: C21H21 N O4
• Molecular Weight: 351.4
• Hs Code.: 2918990090
• Mol file: 106287-91-6.mol

Synonyms:

Chemical Property of 1-(4-Methylphenacyl)-2-methyl-5-methoxyindol-3-ylacetic acid

Chemical Property:

• Vapor Pressure: 7.76E-15mmHg at 25°C
• Boiling Point: 591.5°C at 760 mmHg
• Flash Point: 311.5°C
• PSA: 68.53000
• Density: 1.2g/cm³
• LogP: 3.77670

Purity/Quality:

1-(4-METHYLPHENACYL)-2-METHYL-5-METHOXYINDOL-3-YLACETIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-Methylphenacyl)-2-methyl-5-methoxyindol-3-ylacetic acid

There total 3 articles about 1-(4-Methylphenacyl)-2-methyl-5-methoxyindol-3-ylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

[5-Methoxy-2-methyl-1-(2-oxo-2-p-tolyl-ethyl)-1H-indol-3-yl]-acetic acid methyl ester (106287-87-0) → [5-Methoxy-2-methyl-1-(2-oxo-2-p-tolyl-ethyl)-1H-indol-3-yl]-acetic acid (106287-91-6)

Guidance literature:

With sodium hydroxide; In ethanol; for 0.5h; Heating;

DOI:10.1007/BF00763782

Reference yield:

4-(4-methoxy-phenylhydrazono)-valeric acid methyl ester (53258-38-1) → [5-Methoxy-2-methyl-1-(2-oxo-2-p-tolyl-ethyl)-1H-indol-3-yl]-acetic acid (106287-91-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) MeI / 1.) DMF, 80 deg C, 8 h, 2.) 80 deg C, 20 h

2: 93 percent / NaOH / aq. ethanol / 0.5 h / Heating

With sodium hydroxide; methyl iodide; In ethanol;

DOI:10.1007/BF00763782

Reference yield:

4-(bromoacetyl)toluene (619-41-0) → [5-Methoxy-2-methyl-1-(2-oxo-2-p-tolyl-ethyl)-1H-indol-3-yl]-acetic acid (106287-91-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) MeI / 1.) DMF, 80 deg C, 8 h, 2.) 80 deg C, 20 h

2: 93 percent / NaOH / aq. ethanol / 0.5 h / Heating

With sodium hydroxide; methyl iodide; In ethanol;

DOI:10.1007/BF00763782

upstream raw materials:

[5-Methoxy-2-methyl-1-(2-oxo-2-p-tolyl-ethyl)-1H-indol-3-yl]-acetic acid methyl ester

4-(4-methoxy-phenylhydrazono)-valeric acid methyl ester

4-(bromoacetyl)toluene

Refernces