7-CHLOROISATIN

Base Information

• Chemical Name: 7-CHLOROISATIN
• CAS No.: 7477-63-6
• Molecular Formula: C8H4ClNO2
• Molecular Weight: 181.578
• Hs Code.: 2933990090
• Mol file: 7477-63-6.mol

Synonyms:Indole-2,3-dione,7-chloro- (8CI);Isatin, 7-chloro- (6CI);7-Chloro-1H-indole-2,3-dione;7-Chloro-2,3-indolinedione;7-Chloroindole-2,3-dione;NSC400868;

Chemical Property of 7-CHLOROISATIN

Chemical Property:

• Appearance/Colour: Orange Powder
• Melting Point: 187-191 °C
• Refractive Index: 1.626
• PKA: 8.60±0.20(Predicted)
• PSA: 46.17000
• Density: 1.519 g/cm³
• LogP: 1.61280
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

7-Chloroisatin ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,Xi
• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38
• Safety Statements: 26-36/37/38

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-CHLOROISATIN

There total 1 articles about 7-CHLOROISATIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylantimony(III) bis(7-chloroisatin) (152582-21-3) → 7-chloroisatin (7477-63-6) + diphenylantimony(III) bromide (50518-68-8)

Guidance literature:

With bromine; In tetrachloromethane; slow addn. of bromine in CCl4 to a soln. of Sb-compd. in CCl4 at -5°C over 30 min in a N2 atmosphere, colour of bromine disappears readily after each addn., but at the end a light brown colour persists; warming to room temp., removal of volatiles in vacuo, monitoring residue by IR;

Reference yield: 96.0%

7-chloroisatin (7477-63-6) + 3-amino-1-phenyl-2-pyrazolin-5-one (4149-06-8) + inden-1-one (83-33-0) → 7'-chloro-2-phenyl-1,2,5,10-tetrahydro-3H-spiro[indeno[1,2-b]pyrazolo[4,3-e]pyridine-4,3'-indoline]-2',3-dione

Guidance literature:

With acetic acid; In water; at 90 ℃; for 5h; Green chemistry;

DOI:10.1016/j.tet.2016.12.015

Reference yield: 94.0%

7-chloroisatin (7477-63-6) + 1-Phenyl-3-methyl-5-aminopyrazole (1131-18-6) + 6-Amino-1,3-dimethylbarbituric acid (6642-31-5) → 7-chloro-3',6',8'-trimethyl-1'-phenyl-1',9'-dihydrospiro[indoline-3,4'-pyrazolo[4',3':5,6]pyrido[2,3-d]pyrimidine]-2,5',7'(6'H,8'H)-trione

Guidance literature:

With acetic acid; In water; at 90 ℃; for 7h; Green chemistry;

DOI:10.1007/s11164-018-3642-3

upstream raw materials:

phenylantimony(III) bis(7-chloroisatin)

Downstream raw materials:

8-chloro-2-(4-chlorophenyl)cinchoninic acid

2-amino-3-chlorobenzoic acid

7-Chloro-3-hydroxy-3-(2-oxo-2-thiophen-2-yl-ethyl)-1,3-dihydro-indol-2-one

8-chloro-2H-benzo[d][1,3]oxazine-2,4(1H)-dione