3-benzylsydnone

Base Information

• Chemical Name: 3-benzylsydnone
• CAS No.: 16844-42-1
• Molecular Formula: C9H8 N2 O2
• Molecular Weight: 176.175
• Hs Code.: 2934999090
• Mol file: 16844-42-1.mol

Synonyms:Sydnone,3-(phenylmethyl)-; Sydnone, 3-benzyl- (6CI,7CI,8CI); 3-Benzylsydnone; Benzylsydnone; NSC 50486

Chemical Property of 3-benzylsydnone

Chemical Property:

• PSA: 50.14000
• LogP: 0.71600

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-benzylsydnone

There total 9 articles about 3-benzylsydnone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-benzylglycine (17136-36-6) → 3-benzylsydnone (16844-42-1)

Guidance literature:

Multi-step reaction with 2 steps

1: conc. HCl, aq. NaNO₂ / 2 h

2: trifluoroacetic anhydride / ethyl acetate / 1 h

With hydrogenchloride; trifluoroacetic anhydride; sodium nitrite; In ethyl acetate;

DOI:10.1002/jhet.5570330333

Reference yield:

N-benzyl glycine hydrochloride (7689-50-1) → 3-benzylsydnone (16844-42-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / NaNO₂ / H₂O / 1.) 5 deg C, 0.5h, 2.) room temperature, 1h

2: 72 percent / acetic anhydride / 5 h / hot water bath

With acetic anhydride; sodium nitrite; In water;

DOI:10.1021/jo00157a011

Reference yield:

ethyl 2-(benzylamino)acetate (6436-90-4) → 3-benzylsydnone (16844-42-1)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. NaOH / 0.67 h / Heating

2: conc. HCl, aq. NaNO₂ / 2 h

3: trifluoroacetic anhydride / ethyl acetate / 1 h

With hydrogenchloride; sodium hydroxide; trifluoroacetic anhydride; sodium nitrite; In ethyl acetate;

DOI:10.1002/jhet.5570330333

upstream raw materials:

3-Benzyl-N-nitroso-5-sydnone imine

3-(carboxy-phenyl-methyl)-sydnone

ethyl 2-(benzylamino)acetate

N-benzylglycine

Downstream raw materials:

3-(1,2-diphenyl-ethyl)-sydnone

3-benzyl-4-methylsulfanyl-sydnone

3-benzyl-4-formyl-sydnone

1-benzyl-1,4-dihydro-4-isopropylidene-5H-1,2-diazepin-5-one