4-(2H-Indazol-2-yl)-alpha-methylbenzeneacetamide

Base Information

Chemical Name:4-(2H-Indazol-2-yl)-alpha-methylbenzeneacetamide
CAS No.:81265-81-8
Molecular Formula:C₁₆H₁₅N₃O
Molecular Weight:265.315
Hs Code.:
DSSTox Substance ID:DTXSID701001901

Synonyms:M.G. 18804;4-(2H-Indazol-2-yl)-alpha-methylbenzeneacetamide;2-(4-(2H-Indazol-2-il)fenil)propionammide [Italian];Benzeneacetamide, 4-(2H-indazol-2-yl)-alpha-methyl-;2-(4-(2H-Indazol-2-il)fenil)propionammide;81265-81-8;DTXSID701001901;LS-28565;2-[4-(2H-Indazol-2-yl)phenyl]propanimidic acid

Suppliers and Price of 4-(2H-Indazol-2-yl)-alpha-methylbenzeneacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 4-(2H-Indazol-2-yl)-alpha-methylbenzeneacetamide

Chemical Property:

Vapor Pressure:1.99E-06mmHg at 25°C
Boiling Point:394.4°C at 760 mmHg
Flash Point:192.3°C
Density:1.24g/cm³
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:265.121512110
Heavy Atom Count:20
Complexity:352

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C1=CC=C(C=C1)N2C=C3C=CC=CC3=N2)C(=O)N

Technology Process of 4-(2H-Indazol-2-yl)-alpha-methylbenzeneacetamide

There total 4 articles about 4-(2H-Indazol-2-yl)-alpha-methylbenzeneacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32868-25-0
2-(4-amminofenil)propionico d'etile

: 81265-81-8
2-<4-(2H-indazol-2-il)fenil>propionammide

Guidance literature:: Multi-step reaction with 3 steps

1: 2.) triethyl phosphite / 1.) methanol, 4 h, reflux; 2.) 8 h, 150 deg C

2: 67 percent / NaOH / ethanol; H₂O / 12 h / Heating

3: 1.) triethylamine, ethyl chlorocarbonate; 2.) 32percent NH₄OH / 1.) THF, 30 min, -10 deg C; 2.) THF, 3 h, r.t.

With ammonium hydroxide; sodium hydroxide; chloroformic acid ethyl ester; triethylamine; triethyl phosphite; In ethanol; water;

Reference yield:

: 81265-53-4
estere etilico dell'acido 2-<4-(2H-indazol-2-il)fenil>propionico

: 81265-81-8
2-<4-(2H-indazol-2-il)fenil>propionammide

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / NaOH / ethanol; H₂O / 12 h / Heating

2: 1.) triethylamine, ethyl chlorocarbonate; 2.) 32percent NH₄OH / 1.) THF, 30 min, -10 deg C; 2.) THF, 3 h, r.t.

With ammonium hydroxide; sodium hydroxide; chloroformic acid ethyl ester; triethylamine; In ethanol; water;

Reference yield:

: 552-89-6
2-nitro-benzaldehyde

: 81265-81-8
2-<4-(2H-indazol-2-il)fenil>propionammide

Guidance literature:: Multi-step reaction with 3 steps

1: 2.) triethyl phosphite / 1.) methanol, 4 h, reflux; 2.) 8 h, 150 deg C

2: 67 percent / NaOH / ethanol; H₂O / 12 h / Heating

3: 1.) triethylamine, ethyl chlorocarbonate; 2.) 32percent NH₄OH / 1.) THF, 30 min, -10 deg C; 2.) THF, 3 h, r.t.

With ammonium hydroxide; sodium hydroxide; chloroformic acid ethyl ester; triethylamine; triethyl phosphite; In ethanol; water;