4-Methoxy-23,24,25-triazatetracyclo[18.2.1.12,5.17,10]pentacosa-1(22),2(25),3,5,7,9,20-heptaene

Base Information

Chemical Name:4-Methoxy-23,24,25-triazatetracyclo[18.2.1.12,5.17,10]pentacosa-1(22),2(25),3,5,7,9,20-heptaene
CAS No.:34852-35-2
Molecular Formula:C23H29N3O
Molecular Weight:363.5
Hs Code.:29419000

Synonyms:

Suppliers and Price of 4-Methoxy-23,24,25-triazatetracyclo[18.2.1.12,5.17,10]pentacosa-1(22),2(25),3,5,7,9,20-heptaene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Methoxy-23,24,25-triazatetracyclo[18.2.1.12,5.17,10]pentacosa-1(22),2(25),3,5,7,9,20-heptaene

Chemical Property:

Boiling Point:643.5±55.0 °C(Predicted)
PKA:15.80±0.40(Predicted)
PSA：53.17000
Density:1.17±0.1 g/cm3(Predicted)
LogP:4.98180

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-Methoxy-23,24,25-triazatetracyclo[18.2.1.12,5.17,10]pentacosa-1(22),2(25),3,5,7,9,20-heptaene

There total 15 articles about 4-Methoxy-23,24,25-triazatetracyclo[18.2.1.12,5.17,10]pentacosa-1(22),2(25),3,5,7,9,20-heptaene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 776281-15-3
C₂₃H₂₇N₃O

: 34852-35-2
2⁴-methoxy-1¹H,4¹H-1,2,4(2,5)-tripyrrola-cyclotridecaphan-2-ene

Guidance literature:: With RhCl(PPh₃)3; hydrogen; In ethanol; at 20 ℃; for 6h; under 760 Torr;
DOI:10.1021/jo991021i

Reference yield:

: 591-80-0
pent-4-enoic acid

: 34852-35-2
2⁴-methoxy-1¹H,4¹H-1,2,4(2,5)-tripyrrola-cyclotridecaphan-2-ene

Guidance literature:: Multi-step reaction with 10 steps

1.1: Ph₃P / toluene / 4 h / 20 °C

2.1: toluene / 1 h / -78 °C

3.1: 63 percent / NaBH₄ / propan-2-ol / 24 h / Heating

4.1: 92 percent / DMAP / CH₂Cl₂ / 20 °C

5.1: lithium 2,2,6,6-tetramethylpiperidine / tetrahydrofuran / 2 h / -78 °C

5.2: tetrahydrofuran / -78 - 20 °C

6.1: aq. HCl

7.1: LiCl; Pd(PPh₃)4; aq. Na₂CO₃ / 1,2-dimethoxy-ethane / 15 h / 85 °C

8.1: HCl / diethyl ether

9.1: Cl₂Ru(PCy₃)2-3-Ph-indenylidene / CH₂Cl₂ / 16 h / Heating

10.1: RhCl(PPh₃)3; H₂ / ethanol / 6 h / 20 °C / 760 Torr

With hydrogenchloride; dmap; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(tricyclohexylphosphine)-3-phenyl-1H-inden-1-ylidene ruthenium(II) dichloride; RhCl(PPh₃)3; 2,2,6,6-tetramethylpiperidinyl-lithium; hydrogen; sodium carbonate; triphenylphosphine; lithium chloride; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; ethanol; dichloromethane; isopropyl alcohol; toluene; 1.1: Substitution / 2.1: Grignard reaction / 3.1: Reduction / 4.1: Substitution / 5.1: Metallation / 5.2: Substitution / 6.1: Hydrolysis / 7.1: Substitution / 8.1: Addition / 9.1: Cyclization / 10.1: Reduction;
DOI:10.1021/jo991021i

Reference yield:

: 143582-21-2
1-(1H-pyrrol-2-yl)hex-5-en-1-one

: 34852-35-2
2⁴-methoxy-1¹H,4¹H-1,2,4(2,5)-tripyrrola-cyclotridecaphan-2-ene

Guidance literature:: Multi-step reaction with 8 steps

1.1: 65 percent / NaBH₄ / propan-2-ol / 24 h / Heating

2.1: POCl₃ / 1,2-dichloro-ethane / 0 °C

2.2: 80 percent / 1,2-dichloro-ethane / 0 °C / Heating

3.1: 94 percent / aq. NaOH / dimethylsulfoxide / 24 h / 60 °C

4.1: 93 percent / CH₂Cl₂ / 1 h / 0 °C

5.1: LiCl; Pd(PPh₃)4; aq. Na₂CO₃ / 1,2-dimethoxy-ethane / 15 h / 85 °C

6.1: HCl / diethyl ether

7.1: Cl₂Ru(PCy₃)2-3-Ph-indenylidene / CH₂Cl₂ / 16 h / Heating

8.1: RhCl(PPh₃)3; H₂ / ethanol / 6 h / 20 °C / 760 Torr

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(tricyclohexylphosphine)-3-phenyl-1H-inden-1-ylidene ruthenium(II) dichloride; RhCl(PPh₃)3; hydrogen; sodium carbonate; lithium chloride; trichlorophosphate; In 1,2-dimethoxyethane; diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; isopropyl alcohol; 1.1: Reduction / 2.1: Addition / 2.2: Formylation / 3.1: Condensation / 4.1: Addition / 5.1: Substitution / 6.1: Addition / 7.1: Cyclization / 8.1: Reduction;
DOI:10.1021/jo991021i