Chemical Property of Phomopsin A
Chemical Property:
- Vapor Pressure:0mmHg at 25°C
- Boiling Point:1188.2°C at 760 mmHg
- PKA:2.27±0.36(Predicted)
- Flash Point:672.4°C
- PSA：273.03000
- Density:1.48g/cm3
- LogP:2.27850
- Storage Temp.:2-8°C
- Solubility.:DMSO (Slightly), Methanol (Very Slightly)
- XLogP3:0.3
- Hydrogen Bond Donor Count:9
- Hydrogen Bond Acceptor Count:13
- Rotatable Bond Count:11
- Exact Mass:788.2783986
- Heavy Atom Count:55
- Complexity:1660
- Purity/Quality:
-
99% *data from raw suppliers
Phomopsin A *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:Xn
- Statements:
20/21/22-40
- Safety Statements:
36/37/39
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CCC(=C(C(=O)NC(=CC(=O)O)C(=O)O)NC(=O)C1C=CCN1C(=O)C2C(OC3=C(C(=CC(=C3)C(C(C(=O)NC(C(=O)N2)C(=C)C)NC)O)Cl)O)(C)CC)C
- Isomeric SMILES:CC/C(=C(\C(=O)N/C(=C/C(=O)O)/C(=O)O)/NC(=O)[C@@H]1C=CCN1C(=O)[C@@H]2[C@@](OC3=C(C(=CC(=C3)[C@@H]([C@@H](C(=O)N[C@H](C(=O)N2)C(=C)C)NC)O)Cl)O)(C)CC)/C
-
Uses
Phomopsin A is a an acidic 13-membered cyclic hexapeptide-like metabolite with three unusual amino acids linked in an ‘ansa’ macrocycle with a tripeptide tail, terminating in a dicarboxylic acid. Phomopsin A is a potent mycotoxin produced by the fungus, Phomopsis leptostromiformis, and causes lupinosis in livestock fed infected lupins. Phomopsin A is an important bioprobe for understanding cellular structural proteins. It binds selectively to dimeric tubulin at a site overlapping that of vinblastine and maytansine, inhibiting the formation of the microtubule spindle to block cell division. Uniquely, phomopsin A protects tubulin from decay. Phomopsin A is a potent microtubule inhibitor.
