N-Benzyloxycarbonyl-O-tert-butyl-L-tyrosine dicyclohexylamine salt

Base Information

• Chemical Name: N-Benzyloxycarbonyl-O-tert-butyl-L-tyrosine dicyclohexylamine salt
• CAS No.: 16879-90-6
• Molecular Formula: C21H25NO5^.C12H23N
• Molecular Weight: 552.755
• Mol file: 16879-90-6.mol

Synonyms:Z-Tyr(tBu)-OH·DCHA;Z-O-tert·butyl-L-tyrosine dicyclohexylamine salt;N-((Benzyloxy)carbonyl)-O-(tert-butyl)-L-tyrosine, compound with dicyclohexylamine (1:1);Cbz-Tyr(tbu)-OH.DCHA;

Chemical Property of N-Benzyloxycarbonyl-O-tert-butyl-L-tyrosine dicyclohexylamine salt

Chemical Property:

• Appearance/Colour: white powder
• Vapor Pressure: 3.12E-13mmHg at 25°C
• Melting Point: 158-161 °C
• Boiling Point: 556.8 °C at 760 mmHg
• Flash Point: 290.5 °C
• PSA: 96.89000
• Density: 1.185 g/cm³
• LogP: 7.80920
• Storage Temp.: −20°C

Purity/Quality:

98% ^*data from raw suppliers

Z-Tyr(tBu)-OHDCHA ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Composition and Structure: Z-Tyr(tBu)-OH.DCHA is a protected form of the amino acid tyrosine, containing a tert-butyl (tBu) group and an N-protecting group Z.
• Uses: Used as a key component in the synthesis of peptides, particularly in the creation of peptide bonds.; Employed in drug discovery efforts as a starting material or intermediate in the synthesis of pharmaceutical compounds.
• Storage: Should be stored at -20°C in a dry, well-ventilated area away from heat or flames to maintain stability.

Technology Process of N-Benzyloxycarbonyl-O-tert-butyl-L-tyrosine dicyclohexylamine salt

There total 1 articles about N-Benzyloxycarbonyl-O-tert-butyl-L-tyrosine dicyclohexylamine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ N-[(benzyloxy)carbonyl]-O-(tert-butyl)-L-tyrosine, compound with dicyclohexylamine (1:1) (16879-90-6,198828-72-7)

Guidance literature:

aus den Komponenten;

Reference yield: 85.0%

N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride (2389-48-2) + N-α-benzyloxycarbamoyl-O-t-butyl-L-tyrosine dicyclohexylammonium salt (16879-90-6,198828-72-7) → Z-tyrosine(OtBu)N-ε-(tBoc)lysine methyl ester

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 6h;

DOI:10.1021/ja039562j

Reference yield: 83.0%

N-α-benzyloxycarbamoyl-O-t-butyl-L-tyrosine dicyclohexylammonium salt (16879-90-6,198828-72-7) + ((S)-2-Amino-propionylamino)-acetic acid octadecyl ester; hydrobromide → {(S)-2-[(S)-2-Benzyloxycarbonylamino-3-(4-tert-butoxy-phenyl)-propionylamino]-propionylamino}-acetic acid octadecyl ester

Guidance literature:

With 4-methyl-morpholine; pivaloyl chloride; In chloroform; 1.) -15 deg C, 60 min., 2.) 20 deg C, 2 h;

Downstream raw materials:

O-t-Butyl-L-tyrosine

N-Cbz-N-methyl-(O-tert-butyl)tyrosine

Z-Tyr(tBu)-Pro-O-tBu

Val-Val-Tyr(tBu)-Pro-O-tBu