Z-Tyr(tBu)-OH.DCHA

Base Information

• Chemical Name: Z-Tyr(tBu)-OH.DCHA
• CAS No.: 16879-90-6
• Molecular Formula: C21H25NO5^.C12H23N
• Molecular Weight: 552.755
• European Community (EC) Number: 240-910-7
• DSSTox Substance ID: DTXSID00937549
• Mol file: 16879-90-6.mol

Synonyms:16879-90-6;Z-Tyr(tBu)-OH.DCHA;Z-Tyr(tbu)-oh dcha;Dicyclohexylamine (S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(tert-butoxy)phenyl)propanoate;N-cyclohexylcyclohexanamine;(2S)-3-[4-[(2-methylpropan-2-yl)oxy]phenyl]-2-(phenylmethoxycarbonylamino)propanoic acid;Nalpha-Cbz-O-tert-butyl-L-tyrosine Dicyclohexylammonium Salt;Cbz-Tyr(tBu)-OH.DCHA;MFCD00038245;C33H48N2O5;Z-Tyr(tBu)-OH dicyclohexylammonium salt;EINECS 240-910-7;Z-Tyr(tBu)-OH (dicyclohexylammonium) salt;Z-Tyr(tBu)-OH?DCHA;DTXSID00937549;AC8094;AKOS016842915;CS-W009603;HY-W008887;Dicyclohexylamine (S)-2-(((benzyloxy)carbonyl)-amino)-3-(4-(tert-butoxy)phenyl)propanoate;N-((Benzyloxy)carbonyl)-O-(tert-butyl)-L-tyrosine, compound with dicyclohexylamine (1:1);AS-12122;NS00051864;W-107897;(2S)-2-{[(BENZYLOXY)CARBONYL]AMINO}-3-[4-(TERT-BUTOXY)PHENYL]PROPANOIC ACID;DICHA;dicyclohexylamine (S)-2-(benzyloxycarbonylamino)-3-(4-tert-butoxyphenyl)propanoate;N-[(Benzyloxy)(hydroxy)methylidene]-O-tert-butyltyrosine--N-cyclohexylcyclohexanamine (1/1);N-alpha-BenZyloxycarbonyl-O-t-butyl-L-tyrosine dicyclohexylamine (CbZ-L-Tyr(tBu)-OH.DCHA);(S)-2-(((Benzyloxy)carbonyl)amino)-3-(4-(tert-butoxy)phenyl)propanoic acid dicyclohexylammonium salt

Chemical Property of Z-Tyr(tBu)-OH.DCHA

Chemical Property:

• Appearance/Colour: white powder
• Vapor Pressure: 3.12E-13mmHg at 25°C
• Melting Point: 158-161 °C
• Boiling Point: 556.8 °C at 760 mmHg
• Flash Point: 290.5 °C
• PSA: 96.89000
• Density: 1.185 g/cm³
• LogP: 7.80920
• Storage Temp.: −20°C
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 11
• Exact Mass: 552.35632264
• Heavy Atom Count: 40
• Complexity: 590

Purity/Quality:

98% ^*data from raw suppliers

Z-Tyr(tBu)-OHDCHA ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC1=CC=C(C=C1)CC(C(=O)O)NC(=O)OCC2=CC=CC=C2.C1CCC(CC1)NC2CCCCC2
• Isomeric SMILES: CC(C)(C)OC1=CC=C(C=C1)C[C@@H](C(=O)O)NC(=O)OCC2=CC=CC=C2.C1CCC(CC1)NC2CCCCC2
• Chemical Composition and Structure: Z-Tyr(tBu)-OH.DCHA is a protected form of the amino acid tyrosine, containing a tert-butyl (tBu) group and an N-protecting group Z.
• Uses: Used as a key component in the synthesis of peptides, particularly in the creation of peptide bonds.; Employed in drug discovery efforts as a starting material or intermediate in the synthesis of pharmaceutical compounds.
• Storage: Should be stored at -20°C in a dry, well-ventilated area away from heat or flames to maintain stability.

Technology Process of Z-Tyr(tBu)-OH.DCHA

There total 1 articles about Z-Tyr(tBu)-OH.DCHA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ N-[(benzyloxy)carbonyl]-O-(tert-butyl)-L-tyrosine, compound with dicyclohexylamine (1:1) (16879-90-6,198828-72-7)

Guidance literature:

aus den Komponenten;

Reference yield: 85.0%

N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride (2389-48-2) + N-α-benzyloxycarbamoyl-O-t-butyl-L-tyrosine dicyclohexylammonium salt (16879-90-6,198828-72-7) → Z-tyrosine(OtBu)N-ε-(tBoc)lysine methyl ester

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 6h;

DOI:10.1021/ja039562j

Reference yield: 83.0%

N-α-benzyloxycarbamoyl-O-t-butyl-L-tyrosine dicyclohexylammonium salt (16879-90-6,198828-72-7) + ((S)-2-Amino-propionylamino)-acetic acid octadecyl ester; hydrobromide → {(S)-2-[(S)-2-Benzyloxycarbonylamino-3-(4-tert-butoxy-phenyl)-propionylamino]-propionylamino}-acetic acid octadecyl ester

Guidance literature:

With 4-methyl-morpholine; pivaloyl chloride; In chloroform; 1.) -15 deg C, 60 min., 2.) 20 deg C, 2 h;

Downstream raw materials:

N-fluorenylmethoxycarbonyl-O-tertbutyl N-methyltyrosine

C₁₄H₂₁NO₃

O-t-Butyl-L-tyrosine

N-Cbz-N-methyl-(O-tert-butyl)tyrosine