Urea, 1-(4,7-dimethoxy-6-(2-(isopropylamino)ethoxy)-5-benzofuranyl)-3-methyl-

Base Information

Chemical Name:Urea, 1-(4,7-dimethoxy-6-(2-(isopropylamino)ethoxy)-5-benzofuranyl)-3-methyl-
CAS No.:66203-91-6
Molecular Formula:C17H25N3O5
Molecular Weight:351.3975
Hs Code.:
DSSTox Substance ID:DTXSID70216393
Nikkaji Number:J87.665H
Wikidata:Q83092618
ChEMBL ID:CHEMBL45054

Synonyms:BRN 5145007;Urea, 1-(4,7-dimethoxy-6-(2-(isopropylamino)ethoxy)-5-benzofuranyl)-3-methyl-;N-(4,7-Dimethoxy-6-(2-(isopropylamino)ethoxy)-5-benzofuranyl)-N'-methylurea;66203-91-6;CHEMBL45054;DTXSID70216393;LS-159892;1-[4,7-Dimethoxy-6-[2-(isopropylamino)ethoxy]benzofuran-5-yl]-3-methylurea

Suppliers and Price of Urea, 1-(4,7-dimethoxy-6-(2-(isopropylamino)ethoxy)-5-benzofuranyl)-3-methyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Urea, 1-(4,7-dimethoxy-6-(2-(isopropylamino)ethoxy)-5-benzofuranyl)-3-methyl-

Chemical Property:

Vapor Pressure:1.99E-09mmHg at 25°C
Boiling Point:481.4°C at 760 mmHg
Flash Point:245°C
Density:1.189g/cm³
XLogP3:1.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:8
Exact Mass:351.17942091
Heavy Atom Count:25
Complexity:423

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)NCCOC1=C(C2=C(C=CO2)C(=C1NC(=O)NC)OC)OC

Technology Process of Urea, 1-(4,7-dimethoxy-6-(2-(isopropylamino)ethoxy)-5-benzofuranyl)-3-methyl-

There total 6 articles about Urea, 1-(4,7-dimethoxy-6-(2-(isopropylamino)ethoxy)-5-benzofuranyl)-3-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 66203-90-5
N-<6-(2-chloroethoxy)-4,4-dimethoxy-5-benzofuranyl>-N'-methylurea

: 75-31-0
isopropylamine

: 66203-91-6
N-<4,7-dimethoxy-6-<2-(isopropylamino)ethoxy>-5-benzofuranyl>-N'-methylurea

Guidance literature:: With potassium carbonate; sodium iodide; In acetonitrile; for 15h; Heating;
DOI:10.1021/jm00134a007

Reference yield:

: 52631-79-5
N-(4,7-dimethoxy-6-hydroxy-5-benzofuranyl)acetamide

: 66203-91-6
N-<4,7-dimethoxy-6-<2-(isopropylamino)ethoxy>-5-benzofuranyl>-N'-methylurea

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / HCl / ethanol / 20 h / Heating

2: 89 percent / CHCl₃ / 2 h / Ambient temperature

3: 62 percent / K₂CO₃ / acetonitrile / 4.5 h / Heating

4: 18 percent / NaI, K₂CO₃ / acetonitrile / 15 h / Heating

With hydrogenchloride; potassium carbonate; sodium iodide; In ethanol; chloroform; acetonitrile;
DOI:10.1021/jm00134a007

Reference yield:

: 484-51-5
5-acetyl-6-hydroxy-4,7-dimethoxybenzofuran

: 66203-91-6
N-<4,7-dimethoxy-6-<2-(isopropylamino)ethoxy>-5-benzofuranyl>-N'-methylurea

Guidance literature:: Multi-step reaction with 6 steps

1: 82 percent / hydroxylamine hydrochloride, conc. NaOH / ethanol; H₂O / 6 h / Heating

2: 75 percent / aq. AcOH, HCl(g) / 0.5 h / 90 °C

3: 90 percent / HCl / ethanol / 20 h / Heating

4: 89 percent / CHCl₃ / 2 h / Ambient temperature

5: 62 percent / K₂CO₃ / acetonitrile / 4.5 h / Heating

6: 18 percent / NaI, K₂CO₃ / acetonitrile / 15 h / Heating

With hydrogenchloride; sodium hydroxide; hydroxylamine hydrochloride; potassium carbonate; acetic acid; sodium iodide; In ethanol; chloroform; water; acetonitrile;
DOI:10.1021/jm00134a007