Hexanoic acid, 6-[[(1,1-dimethylethoxy)carbonyl]methylamino]-

Base Information

• Chemical Name: Hexanoic acid, 6-[[(1,1-dimethylethoxy)carbonyl]methylamino]-
• CAS No.: 100222-98-8
• Molecular Formula: C12H23NO4
• Molecular Weight: 245.31500
• Mol file: 100222-98-8.mol

Synonyms:Hexanoic acid,6-[[(1,1-dimethylethoxy)carbonyl]methylamino];N-methyl(tert-butyloxycarbonyl)caproic acid;

Chemical Property of Hexanoic acid, 6-[[(1,1-dimethylethoxy)carbonyl]methylamino]-

Chemical Property:

• PSA: 75.63000
• LogP: 1.95360

Purity/Quality:

99% ^*data from raw suppliers

6-[[2-[(2-Methylpropan-2-yl)oxy]-2-oxoethyl]amino]hexanoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Hexanoic acid, 6-[[(1,1-dimethylethoxy)carbonyl]methylamino]-

There total 3 articles about Hexanoic acid, 6-[[(1,1-dimethylethoxy)carbonyl]methylamino]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

tert-butyldicarbonate (34619-03-9) + 6-(methylamino)hexanoic acid hydrochloride (121912-30-9) → 6-(tert-butoxycarbonyl(methyl)amino)hexanoic acid (100222-98-8)

Guidance literature:

With triethylamine; In dichloromethane; for 1h;

DOI:10.1021/bc400333m

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 6-(methylamino)hexanoic acid hydrochloride (121912-30-9) → 6-(tert-butoxycarbonyl(methyl)amino)hexanoic acid (100222-98-8)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; at 0 - 20 ℃; for 16h;

Reference yield:

1-methyl-2-azepanone (2556-73-2) → 6-(tert-butoxycarbonyl(methyl)amino)hexanoic acid (100222-98-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / water / 48 h / Reflux

2: triethylamine / dichloromethane / 1 h

With hydrogenchloride; triethylamine; In dichloromethane; water;

DOI:10.1021/bc400333m

upstream raw materials:

1-methyl-2-azepanone

tert-butyldicarbonate

6-(methylamino)hexanoic acid hydrochloride

di-tert-butyl dicarbonate