6-Methoxy-2-methyl-N-phenyl-4-quinolinamine

Base Information

• Chemical Name: 6-Methoxy-2-methyl-N-phenyl-4-quinolinamine
• CAS No.: 100462-38-2
• Molecular Formula: C17H16N2O
• Molecular Weight: 264.327
• DSSTox Substance ID: DTXSID301263997
• ChEMBL ID: CHEMBL5089224
• Mol file: 100462-38-2.mol

Synonyms:TimTec1_000364;Oprea1_102537;Oprea1_849312;CHEMBL5089224;DTXSID301263997;HMS1535A12;AKOS024274609;6-Methoxy-2-methyl-N-phenyl-4-quinolinamine;SR-01000215946;SR-01000215946-1;BRD-K40873950-001-01-5;100462-38-2

Chemical Property of 6-Methoxy-2-methyl-N-phenyl-4-quinolinamine

Chemical Property:

• XLogP3: 4.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 264.126263138
• Heavy Atom Count: 20
• Complexity: 303

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C2C=C(C=CC2=N1)OC)NC3=CC=CC=C3

Technology Process of 6-Methoxy-2-methyl-N-phenyl-4-quinolinamine

There total 2 articles about 6-Methoxy-2-methyl-N-phenyl-4-quinolinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

4-chloro-6-methoxy-2-methylquinoline (50593-73-2) + aniline (62-53-3) → (6-methoxy-2-methyl-[4]quinolyl)-phenyl-amine (100462-38-2)

Guidance literature:

In ethanol; for 6h; Heating;

DOI:10.1515/HC.2003.9.1.83

Reference yield:

→ (6-methoxy-2-methyl-[4]quinolyl)-phenyl-amine (100462-38-2)

Guidance literature:

4-Chlor-6-methoxy-chinaldin, Anilin;

Reference yield: 55.0%

(6-methoxy-2-methyl-[4]quinolyl)-phenyl-amine (100462-38-2) + 4-nitrobenzaldehdye (555-16-8) → (E)-6-methoxy-4-phenylamino-2-(4-nitrostyryl)quinoline

Guidance literature:

With Trifluoromethanesulfonamide; In N,N-dimethyl-formamide; at 140 ℃; for 0.333333h; Microwave irradiation;

DOI:10.1016/j.tetlet.2019.05.054

upstream raw materials:

4-chloro-6-methoxy-2-methylquinoline

aniline