ethyl 5-hydroxy-1-(2-hydroxyethyl)-2-methyl-1H-indole-3-carboxylate

Base Information

Chemical Name:ethyl 5-hydroxy-1-(2-hydroxyethyl)-2-methyl-1H-indole-3-carboxylate
CAS No.:100718-84-1
Molecular Formula:C₁₄H₁₇NO₄
Molecular Weight:263.293
Hs Code.:
Mol file:100718-84-1.mol

Synonyms:5-Hydroxy-1-(2-hydroxy-aethyl)-2-methyl-indol-3-carbonsaeure-aethylester;5-Hydroxy-1-(2-hydroxy-ethyl)-2-methyl-1H-indole-3-carboxylic acid ethyl ester;

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 5-hydroxy-1-(2-hydroxyethyl)-2-methyl-1H-indole-3-carboxylate

Chemical Property:

PSA：71.69000
LogP:1.82430

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of ethyl 5-hydroxy-1-(2-hydroxyethyl)-2-methyl-1H-indole-3-carboxylate

There total 2 articles about ethyl 5-hydroxy-1-(2-hydroxyethyl)-2-methyl-1H-indole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 5065-82-7
3-(2-Hydroxy-aethylamino)-crotonsaeure-aethylester

: 106-51-4
p-benzoquinone

: 100718-84-1
5-hydroxy-1-(2-hydroxy-ethyl)-2-methyl-indole-3-carboxylic acid ethyl ester

Guidance literature:: With zinc(II) chloride; In dichloromethane; for 1h; Reflux;
DOI:10.1016/j.tetlet.2008.09.087

Reference yield:

: 141-97-9
ethyl acetoacetate

: 100718-84-1
5-hydroxy-1-(2-hydroxy-ethyl)-2-methyl-indole-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / 1 h / Sonication

2: zinc(II) iodide / 0.67 h / 20 °C

With acetic acid; zinc(II) iodide; 2: |Nenitzescu Synthesis;
DOI:10.1002/ejoc.202101045

Reference yield:

: 100718-84-1
5-hydroxy-1-(2-hydroxy-ethyl)-2-methyl-indole-3-carboxylic acid ethyl ester

: 1-[2-(4-ethoxycarbonyl-5-phenyl-1,2,3-triazol-1-yl)ethyl]-3-ethoxycarbonyl-5-methoxy-2-methylindole

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / anhydrous potassium carbonate; potassium iodide / acetone / 40 h / Heating

2: 76 percent / pyridine / 12 h / 20 °C

3: 89 percent / sodium azide / dimethylformamide; H₂O / 6 h / Heating

4: 47 percent / acetone / 12 h / Heating

With pyridine; sodium azide; potassium carbonate; potassium iodide; In water; N,N-dimethyl-formamide; acetone;