1-Aminocyclopentane-1,3-dicarboxylic acid

Base Information

Chemical Name:1-Aminocyclopentane-1,3-dicarboxylic acid
CAS No.:100910-67-6
Molecular Formula:C₇H₁₁NO₄
Molecular Weight:173.169
Hs Code.:
DSSTox Substance ID:DTXSID701272273
Wikipedia:ACPD
Wikidata:Q4650770
Mol file:100910-67-6.mol

Synonyms:(trans)-1-aminocyclopentyl-1,3-dicarboxylate;1-amino-1,3-dicarboxycyclopentane;1-amino-1,3-dicarboxycyclopentane, (cis)-(+-)-isomer;1-amino-1,3-dicarboxycyclopentane, (trans)-(+-)-isomer;1-amino-1,3-dicarboxycyclopentane, (trans)-isomer;1-amino-1,3-dicarboxycyclopentane, cis-(1R,3R)-isomer;1-amino-1,3-dicarboxycyclopentane, cis-(1S,3S)-isomer;1-amino-1,3-dicarboxycyclopentane, trans-(1R,3S)-isomer;1-amino-cyclopentyl-trans-1S,3R-dicarboxylate;1-aminocyclopentane-1,3-dicarboxylic acid;1-aminocyclopentyl-1,3-dicarboxylic acid;1R,3S-ACPD;1S,3R-ACPD;ACPD-1S,3R;cis-1-amino-1,3-cyclopentanecarboxylic acid;cis-ACPD;t-ACPD;trans-1-aminocyclopentane-1,3-dicarboxylate;trans-ACPD

Suppliers and Price of 1-Aminocyclopentane-1,3-dicarboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-Aminocyclopentane-1,3-dicarboxylicAcid
50mg
$ 220.00

Total 0 raw suppliers

Chemical Property of 1-Aminocyclopentane-1,3-dicarboxylic acid

Chemical Property:

PSA：100.62000
LogP:0.35350
XLogP3:-3.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:173.06880783
Heavy Atom Count:12
Complexity:227

Purity/Quality:: 1-Aminocyclopentane-1,3-dicarboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(CC1C(=O)O)(C(=O)O)N

Technology Process of 1-Aminocyclopentane-1,3-dicarboxylic acid

There total 13 articles about 1-Aminocyclopentane-1,3-dicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: (1S,3S)-1-tert-Butoxycarbonylamino-3-cyano-cyclopentanecarboxylic acid ethyl ester

: 39026-63-6,39026-64-7,56827-69-1,67684-64-4,89253-38-3,100910-67-6,111900-31-3,111900-32-4,111900-33-5,477331-06-9
trans-(+/-)-1-amino-1,3-cyclopentanedicarboxylic acid

Guidance literature:: With hydrogenchloride; ammonium hydroxide; Dowex 50WX₈-100; 1.) reflux, 4 h;
DOI:10.1016/S0040-4039(98)00490-0

Reference yield:

: 112896-82-9,112965-97-6,112965-98-7,112965-99-8,122743-40-2,122743-41-3
(5R,7S)-2,4-Dioxo-1,3-diaza-spiro[4.4]nonane-7-carboxylic acid

: 39026-63-6,39026-64-7,56827-69-1,67684-64-4,89253-38-3,100910-67-6,111900-31-3,111900-32-4,111900-33-5,477331-06-9
trans-1-aminocyclopentane-1,3-dicarboxylic acid

Guidance literature:: With barium(II) oxide; at 140 ℃;
DOI:10.1016/S0040-4039(00)82278-9

Reference yield:

: (1S,3S)-3-Acetoxy-1-tert-butoxycarbonylamino-cyclopentanecarboxylic acid ethyl ester

: 39026-63-6,39026-64-7,56827-69-1,67684-64-4,89253-38-3,100910-67-6,111900-31-3,111900-32-4,111900-33-5,477331-06-9
trans-1-aminocyclopentane-1,3-dicarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 66 percent / K₂CO₃ / ethanol

2: Et₃N / CH₂Cl₂ / 17 h / 0 deg C up to RT

3: dimethylformamide / 17 h / 80 °C

4: 1.) 6M HCl; 2.) Dowex 50WX₈-100, 2M aq. NH₃ / 1.) reflux, 4 h

With hydrogenchloride; ammonium hydroxide; Dowex 50WX₈-100; potassium carbonate; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)00490-0