2-Methoxy-N-(2-phenylethyl)pyridine-3-carboxamide

Base Information

Chemical Name:2-Methoxy-N-(2-phenylethyl)pyridine-3-carboxamide
CAS No.:100948-48-9
Molecular Formula:C15H16N2O2
Molecular Weight:256.304
Hs Code.:
DSSTox Substance ID:DTXSID00544712
Wikidata:Q82421943
Mol file:100948-48-9.mol

Synonyms:100948-48-9;2-Methoxy-N-(2-phenylethyl)pyridine-3-carboxamide;SCHEMBL10073072;DTXSID00544712

Suppliers and Price of 2-Methoxy-N-(2-phenylethyl)pyridine-3-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Methoxy-N-(2-phenylethyl)pyridine-3-carboxamide

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:256.121177757
Heavy Atom Count:19
Complexity:277

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=CC=N1)C(=O)NCCC2=CC=CC=C2

Technology Process of 2-Methoxy-N-(2-phenylethyl)pyridine-3-carboxamide

There total 2 articles about 2-Methoxy-N-(2-phenylethyl)pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 64-04-0
phenethylamine

: 53750-65-5
2-methoxypyridine-3-carbonyl chloride

: 100948-48-9
2-Methoxy-N-phenethyl-nicotinamide

Guidance literature:: With sodium carbonate; In chloroform; for 1.25h;
DOI:10.1021/jm00155a030

Reference yield:

: 16498-81-0
2-methoxynicotinic acid

: 100948-48-9
2-Methoxy-N-phenethyl-nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: SO₂Cl₂ / CH₂Cl₂ / 2 h / Heating

2: 100 percent / aq. Na₂CO₃ / CHCl₃ / 1.25 h

With sulfuryl dichloride; sodium carbonate; In dichloromethane; chloroform;
DOI:10.1021/jm00155a030

Reference yield:

: 100948-48-9
2-Methoxy-N-phenethyl-nicotinamide

: N-{2-[4-(Cyano-trimethylsilanyloxy-methyl)-phenyl]-ethyl}-2-methoxy-nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) TiCl₄, 2.) aq. NaHCO₃ / 1.) 0 deg C, 2.5 h

2: ZnI₂ / CH₂Cl₂ / 65 h / Ambient temperature

With titanium tetrachloride; sodium hydrogencarbonate; zinc(II) iodide; In dichloromethane;
DOI:10.1021/jm00155a030