2H-Isoindole-2-acetic acid, 1,3-dihydro-1,3-dioxo-a-2-propenyl-

Base Information

Chemical Name:2H-Isoindole-2-acetic acid, 1,3-dihydro-1,3-dioxo-a-2-propenyl-
CAS No.:101386-28-1
Molecular Formula:C13H11NO4
Molecular Weight:245.235
Hs Code.:

Synonyms:

Suppliers and Price of 2H-Isoindole-2-acetic acid, 1,3-dihydro-1,3-dioxo-a-2-propenyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 2H-Isoindole-2-acetic acid, 1,3-dihydro-1,3-dioxo-a-2-propenyl-

Chemical Property:

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2H-Isoindole-2-acetic acid, 1,3-dihydro-1,3-dioxo-a-2-propenyl-

There total 1 articles about 2H-Isoindole-2-acetic acid, 1,3-dihydro-1,3-dioxo-a-2-propenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85-44-9
phthalic anhydride

: 1069-48-3,7685-44-1
rac-allylglycine

: 101386-28-1
2-(1,3-dioxoisoindolin-2-yl)pent-4-enoic acid

Guidance literature:: at 180 ℃;
DOI:10.1139/v56-071

Reference yield: 47.0%

: 101386-28-1
2-(1,3-dioxoisoindolin-2-yl)pent-4-enoic acid

: 828253-37-8
(4R,6R)-6-[(3R)-4,4-dimethyl-2-oxotetrahydrofuran-3-yloxy]-4-phenyl-1,3-oxazinan-2-one

: 2-{(R)-1-[(4R,6R)-6-((R)-5,5-Dimethyl-2-oxo-tetrahydro-furan-3-yloxy)-2-oxo-4-phenyl-[1,3]oxazinane-3-carbonyl]-but-3-enyl}-isoindole-1,3-dione

: 2-{(S)-1-[(4R,6R)-6-((R)-5,5-Dimethyl-2-oxo-tetrahydro-furan-3-yloxy)-2-oxo-4-phenyl-[1,3]oxazinane-3-carbonyl]-but-3-enyl}-isoindole-1,3-dione

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 20 ℃; for 16h;
DOI:10.1002/ejoc.200600262

Reference yield:

: 101386-28-1
2-(1,3-dioxoisoindolin-2-yl)pent-4-enoic acid

: 691875-73-7
C₃₄H₂₉F₆N₃O₃

Guidance literature:: Multi-step reaction with 5 steps

1.1: diethyl ether

2.1: O₃ / CH₂Cl₂ / -78 °C

2.2: dimethyl sulfide / CH₂Cl₂ / 20 °C

3.1: sodium triacetoxyborohydride / 1,2-dichloro-ethane

4.1: aq. LiOH / dioxane

5.1: 1-[(3-dimethylamino)propyl]-3-ethyl-carbodiimide; HOAT / CH₂Cl₂

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; sodium tris(acetoxy)borohydride; ozone; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,4-dioxane; diethyl ether; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2006.07.011