4-Bromo-1-[(4-methoxyphenyl)methyl]-1H-imidazole-5-carbaldehyde

Base Information

• Chemical Name: 4-Bromo-1-[(4-methoxyphenyl)methyl]-1H-imidazole-5-carbaldehyde
• CAS No.: 101853-88-7
• Molecular Formula: C12H11BrN2O2
• Molecular Weight: 295.136
• DSSTox Substance ID: DTXSID70542169
• Wikidata: Q82418747
• Mol file: 101853-88-7.mol

Synonyms:101853-88-7;4-Bromo-1-(4-methoxybenzyl)-1H-imidazole-5-carbaldehyde;DTXSID70542169;4-Bromo-1-[(4-methoxyphenyl)methyl]-1H-imidazole-5-carbaldehyde

Chemical Property of 4-Bromo-1-[(4-methoxyphenyl)methyl]-1H-imidazole-5-carbaldehyde

Chemical Property:

• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 294.00039
• Heavy Atom Count: 17
• Complexity: 257

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)CN2C=NC(=C2C=O)Br

Technology Process of 4-Bromo-1-[(4-methoxyphenyl)methyl]-1H-imidazole-5-carbaldehyde

There total 3 articles about 4-Bromo-1-[(4-methoxyphenyl)methyl]-1H-imidazole-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

4,5-dibromo-1-(4-methoxybenzyl)imidazole (101853-79-6) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-bromo-1-(4-methoxybenzyl)imidazole-5-carbaldehyde (101853-88-7)

Guidance literature:

With n-butyllithium; In diethyl ether; at -78 ℃;

DOI:10.1039/c39850001428

Reference yield:

2,4,5-tribromo-1-(4-methoxybenzyl)-1H-imidazole (101901-58-0) → 4-bromo-1-(4-methoxybenzyl)imidazole-5-carbaldehyde (101853-88-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / EtMgBr / diethyl ether

2: 50 percent / n-BuLi / diethyl ether / -78 °C

With n-butyllithium; ethylmagnesium bromide; In diethyl ether;

DOI:10.1039/c39850001428

Reference yield:

p-methoxybenzyl chloride (824-94-2) → 4-bromo-1-(4-methoxybenzyl)imidazole-5-carbaldehyde (101853-88-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / Na₂CO₃ / dimethylformamide

2: 73 percent / EtMgBr / diethyl ether

3: 50 percent / n-BuLi / diethyl ether / -78 °C

With n-butyllithium; ethylmagnesium bromide; sodium carbonate; In diethyl ether; N,N-dimethyl-formamide;

DOI:10.1039/c39850001428

upstream raw materials:

4,5-dibromo-1-(4-methoxybenzyl)imidazole

N,N-dimethyl-formamide

2,4,5-tribromo-1-(4-methoxybenzyl)-1H-imidazole

p-methoxybenzyl chloride

Downstream raw materials:

1-(4-methoxybenzyl)-1H-thieno<2,3-d>imidazole-5-carboxylic acid

ethyl 1-(4-methoxybenzyl)-1H-thieno<2,3-d>imidazole-5-carboxylate