Guanosine, N-benzoyl-5'-O-[(4-methoxyphenyl)diphenylmethyl]-2'-O-[tris(1-methyleth yl)silyl]-, 3'-(methyl 4-morpholinylphosphonite)

Base Information

Chemical Name:Guanosine, N-benzoyl-5'-O-[(4-methoxyphenyl)diphenylmethyl]-2'-O-[tris(1-methyleth yl)silyl]-, 3'-(methyl 4-morpholinylphosphonite)
CAS No.:101904-19-2
Molecular Formula:C51H63N6O9PSi
Molecular Weight:963.155
Hs Code.:
Mol file:101904-19-2.mol

Synonyms:

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Chemical Property of Guanosine, N-benzoyl-5'-O-[(4-methoxyphenyl)diphenylmethyl]-2'-O-[tris(1-methyleth yl)silyl]-, 3'-(methyl 4-morpholinylphosphonite)

Chemical Property:

Purity/Quality:

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MSDS Files:: SDS file from LookChem

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Technology Process of Guanosine, N-benzoyl-5'-O-[(4-methoxyphenyl)diphenylmethyl]-2'-O-[tris(1-methyleth yl)silyl]-, 3'-(methyl 4-morpholinylphosphonite)

There total 3 articles about Guanosine, N-benzoyl-5'-O-[(4-methoxyphenyl)diphenylmethyl]-2'-O-[tris(1-methyleth yl)silyl]-, 3'-(methyl 4-morpholinylphosphonite) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 86030-42-4
morpholinomethylphosphonamidic chloride

: 101904-17-0
N²-benzoyl-5'-O-(monomethoxytrityl)-2'-O-(triisopropylsilyl)guanosine

: 101904-19-2
N²-benzoyl-5'-O-(monomethoxytrityl)-2'-O-(triisopropylsilyl)guanosine 3'-N-morpholinomethylphosphoramidite

Guidance literature:: DOI:10.1016/S0040-4039(00)98753-7

Reference yield:

: 70689-35-9
N²-benzoyl-5'-O-(monomethoxytrityl)guanosine

: 101904-19-2
N²-benzoyl-5'-O-(monomethoxytrityl)-2'-O-(triisopropylsilyl)guanosine 3'-N-morpholinomethylphosphoramidite

Guidance literature:: Multi-step reaction with 2 steps

1: 62 percent / imidazole / dimethylformamide

2: 65 percent / diisopropylethylamine / CHCl₃ / Ambient temperature

With 1H-imidazole; N-ethyl-N,N-diisopropylamine; In chloroform; N,N-dimethyl-formamide;
DOI:10.1021/ja00259a037

Reference yield:

: 13154-24-0
triisopropylsilyl chloride

: 101904-19-2
N²-benzoyl-5'-O-(monomethoxytrityl)-2'-O-(triisopropylsilyl)guanosine 3'-N-morpholinomethylphosphoramidite

Guidance literature:: Multi-step reaction with 2 steps

1: 62 percent / imidazole / dimethylformamide

2: 65 percent / diisopropylethylamine / CHCl₃ / Ambient temperature

With 1H-imidazole; N-ethyl-N,N-diisopropylamine; In chloroform; N,N-dimethyl-formamide;
DOI:10.1021/ja00259a037