Adenosine, N-benzoyl-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5'-O-[(4-methoxyphenyl )diphenylmethyl]-, 3'-[methyl bis(1-methylethyl)phosphoramidite]

Base Information

• Chemical Name: Adenosine, N-benzoyl-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5'-O-[(4-methoxyphenyl )diphenylmethyl]-, 3'-[methyl bis(1-methylethyl)phosphoramidite]
• CAS No.: 101904-21-6
• Molecular Formula: C50H63N6O7PSi
• Molecular Weight: 919.145
• Mol file: 101904-21-6.mol

Synonyms:

Chemical Property of Adenosine, N-benzoyl-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5'-O-[(4-methoxyphenyl )diphenylmethyl]-, 3'-[methyl bis(1-methylethyl)phosphoramidite]

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Adenosine, N-benzoyl-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5'-O-[(4-methoxyphenyl )diphenylmethyl]-, 3'-[methyl bis(1-methylethyl)phosphoramidite]

There total 1 articles about Adenosine, N-benzoyl-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5'-O-[(4-methoxyphenyl )diphenylmethyl]-, 3'-[methyl bis(1-methylethyl)phosphoramidite] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N,N-diisopropylmethylphosphonamidic chloride (86030-43-5) + N6-Benzoyl-2'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine (69504-09-2) → N6-benzoyl-5'-O-(monomethoxytrityl)-2'-O-(tert-butyldimethylsilyl)adenosine 3'-N,N-diisopropylmethylphosphoramidite (101904-21-6)

Guidance literature:

With dmap; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 3h;

DOI:10.1016/S0040-4039(00)98753-7

Reference yield:

N6-benzoyl-5'-O-(monomethoxytrityl)-2'-O-(tert-butyldimethylsilyl)adenosine 3'-N,N-diisopropylmethylphosphoramidite (101904-21-6) + 2',3'-di-O-acetyl-uridine (29108-90-5) → C57H64N7O16PSi (128191-37-7)

Guidance literature:

With 1H-tetrazole; 2,3,5-trimethyl-pyridine; iodine; Yield given. Multistep reaction; 1) THF, RT, 3 h, 2) water, THF, 10 min;

DOI:10.1021/jo00302a044

upstream raw materials:

N,N-diisopropylmethylphosphonamidic chloride

N⁶-Benzoyl-2'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine

Downstream raw materials:

C₅₇H₆₄N₇O₁₆PSi