Guanosine, N-benzoyl-5'-O-[(4-methoxyphenyl)diphenylmethyl]-2'-O-[tris(1-methyleth yl)silyl]-, 3'-[methyl bis(1-methylethyl)phosphoramidite]

Base Information

Chemical Name:Guanosine, N-benzoyl-5'-O-[(4-methoxyphenyl)diphenylmethyl]-2'-O-[tris(1-methyleth yl)silyl]-, 3'-[methyl bis(1-methylethyl)phosphoramidite]
CAS No.:101904-23-8
Molecular Formula:C53H69N6O8PSi
Molecular Weight:977.226
Hs Code.:

Guanosine,
N-benzoyl-5'-O-[(4-methoxyphenyl)diphenylmethyl]-2'-O-[tris(1-methyleth
yl)silyl]-, 3'-[methyl bis(1-methylethyl)phosphoramidite]

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Guanosine, N-benzoyl-5'-O-[(4-methoxyphenyl)diphenylmethyl]-2'-O-[tris(1-methyleth yl)silyl]-, 3'-[methyl bis(1-methylethyl)phosphoramidite]

Chemical Property:

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MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Guanosine, N-benzoyl-5'-O-[(4-methoxyphenyl)diphenylmethyl]-2'-O-[tris(1-methyleth yl)silyl]-, 3'-[methyl bis(1-methylethyl)phosphoramidite]

There total 3 articles about Guanosine, N-benzoyl-5'-O-[(4-methoxyphenyl)diphenylmethyl]-2'-O-[tris(1-methyleth yl)silyl]-, 3'-[methyl bis(1-methylethyl)phosphoramidite] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 86030-43-5
N,N-diisopropylmethylphosphonamidic chloride

: 101904-17-0
N²-benzoyl-5'-O-(monomethoxytrityl)-2'-O-(triisopropylsilyl)guanosine

: 101904-23-8
N²-benzoyl-5'-O-(monomethoxytrityl)-2'-O-(triisopropylsilyl)guanosine 3'-N,N-diisopropylmethylphosphoramidite

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 3h;
DOI:10.1016/S0040-4039(00)98753-7

Reference yield:

: 70689-35-9
N²-benzoyl-5'-O-(monomethoxytrityl)guanosine

: 101904-23-8
N²-benzoyl-5'-O-(monomethoxytrityl)-2'-O-(triisopropylsilyl)guanosine 3'-N,N-diisopropylmethylphosphoramidite

Guidance literature:: Multi-step reaction with 2 steps

1: 62 percent / imidazole / dimethylformamide

2: 83 percent / diisopropylethylamine / tetrahydrofuran / Ambient temperature

With 1H-imidazole; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ja00259a037

Reference yield:

: 13154-24-0
triisopropylsilyl chloride

: 101904-23-8
N²-benzoyl-5'-O-(monomethoxytrityl)-2'-O-(triisopropylsilyl)guanosine 3'-N,N-diisopropylmethylphosphoramidite

Guidance literature:: Multi-step reaction with 2 steps

1: 62 percent / imidazole / dimethylformamide

2: 83 percent / diisopropylethylamine / tetrahydrofuran / Ambient temperature

With 1H-imidazole; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ja00259a037