1,1-Bis[4-(dimethylamino)phenyl]-2-propyn-1-ol

Base Information

• Chemical Name: 1,1-Bis[4-(dimethylamino)phenyl]-2-propyn-1-ol
• CAS No.: 102164-16-9
• Molecular Formula: C19H22N2O
• Molecular Weight: 294.396
• Mol file: 102164-16-9.mol

Synonyms:1,1-di(p-dimethylaminophenyl)prop-2-in-1-ol;1,1-dichloro-2-phenylethylene;3,3-Bis-[4-dimethylamino-phenyl]propin-(1)-ol-(3);1,1-Bis-(4-dimethylamino-phenyl)-prop-2-in-1-ol;1,1-BIS(4-DIMETHYLAMINOPHENYL)-2-PROPYN-1-OL;1,1-bis(4-dimethylaminophenyl)prop-2-yn-1-ol;

Chemical Property of 1,1-Bis[4-(dimethylamino)phenyl]-2-propyn-1-ol

Chemical Property:

• PSA: 26.71000
• LogP: 2.68770

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,1-Bis[4-(dimethylamino)phenyl]-2-propyn-1-ol

There total 5 articles about 1,1-Bis[4-(dimethylamino)phenyl]-2-propyn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

bis(p-dimethylaminophenyl)methanone (90-94-8) + acetylene (74-86-2,25067-58-7) → 1,1-di[4,4'-bis(dimethylamino)phenyl]-2-propyn-1-ol (102164-16-9)

Guidance literature:

With lithium acetylide-ethylenediamine complex; In tetrahydrofuran; 1) 1.5 h, -10 deg C; 2) 1.5 h, r.t.;

DOI:10.1246/bcsj.61.2253

Reference yield: 95.0%

lithium acetylide-ethylenediamine complex (1216963-74-4) + bis(p-dimethylaminophenyl)methanone (90-94-8) → 1,1-di[4,4'-bis(dimethylamino)phenyl]-2-propyn-1-ol (102164-16-9)

Guidance literature:

In tetrahydrofuran; at 0 ℃; for 1.5h;

DOI:10.1246/cl.1986.329

Reference yield: 86.0%

bis(p-dimethylaminophenyl)methanone (90-94-8) + trimethylsilylacetylene (1066-54-2) → 1,1-di[4,4'-bis(dimethylamino)phenyl]-2-propyn-1-ol (102164-16-9)

Guidance literature:

trimethylsilylacetylene; With n-butyllithium; In tetrahydrofuran; hexane; at -10 ℃; for 1h;

bis(p-dimethylaminophenyl)methanone; In tetrahydrofuran; hexane; for 3h;

With potassium hydroxide; In tetrahydrofuran; methanol; hexane; at 0 - 20 ℃; for 0.25h; Further stages.;

DOI:10.1002/ejoc.200390176

upstream raw materials:

lithium acetylide-ethylenediamine complex

bis(p-dimethylaminophenyl)methanone

acetylene

lithium acetylide

Downstream raw materials:

1,1-bis-(4-dimethylamino-phenyl)-6-methyl-hepta-2,4-diyne-1,6-diol

1,1-bis-(4-dimethylamino-phenyl)-octa-2,4,6-triyn-1-ol

1,1-bis-(4-dimethylamino-phenyl)-6,6-diphenyl-hexa-2,4-diyne-1,6-diol

1,1-Bis--4,4-bis-<4-dimethylaminophenyl>-butindiol-(1,4)