(7bR)-1,2,8,8a-Tetrahydro-2-(1H-indol-2-ylcarbonyl)-7-methylcyclopropa(c)pyrrolo(3,2-e)indol-4(5H)-one

Base Information

Chemical Name:(7bR)-1,2,8,8a-Tetrahydro-2-(1H-indol-2-ylcarbonyl)-7-methylcyclopropa(c)pyrrolo(3,2-e)indol-4(5H)-one
CAS No.:110352-06-2
Molecular Formula:C₂₁H₁₇N₃O₂
Molecular Weight:343.385
Hs Code.:
DSSTox Substance ID:DTXSID70911614
ChEMBL ID:CHEMBL154413
Mol file:110352-06-2.mol

Synonyms:(+)-AB;110352-06-2;(7bR)-1,2,8,8a-Tetrahydro-2-(1H-indol-2-ylcarbonyl)-7-methylcyclopropa(c)pyrrolo(3,2-e)indol-4(5H)-one;Cyclopropa(c)pyrrolo(3,2-e)indol-4(5H)-one, 1,2,8,8a-tetrahydro-2-(1H-indol-2-ylcarbonyl)-7-methyl-, (7bR)-;CHEMBL154413;DTXSID70911614;6-(1H-Indole-2-carbonyl)-3-methyl-4,4a,5,6-tetrahydrocyclopropa[c]pyrrolo[3,2-e]indol-8(1H)-one

Suppliers and Price of (7bR)-1,2,8,8a-Tetrahydro-2-(1H-indol-2-ylcarbonyl)-7-methylcyclopropa(c)pyrrolo(3,2-e)indol-4(5H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 3 raw suppliers

Chemical Property of (7bR)-1,2,8,8a-Tetrahydro-2-(1H-indol-2-ylcarbonyl)-7-methylcyclopropa(c)pyrrolo(3,2-e)indol-4(5H)-one

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:343.132076794
Heavy Atom Count:26
Complexity:718

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CNC2=C1C34CC3CN(C4=CC2=O)C(=O)C5=CC6=CC=CC=C6N5

Technology Process of (7bR)-1,2,8,8a-Tetrahydro-2-(1H-indol-2-ylcarbonyl)-7-methylcyclopropa(c)pyrrolo(3,2-e)indol-4(5H)-one

There total 9 articles about (7bR)-1,2,8,8a-Tetrahydro-2-(1H-indol-2-ylcarbonyl)-7-methylcyclopropa(c)pyrrolo(3,2-e)indol-4(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 122330-65-8
((R)-5-Benzyloxy-8-methyl-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indol-1-yl)-methanol

: 101134-70-7,104636-99-9,110352-06-2,128049-45-6
C₂₁H₁₇N₃O₂

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / tetrahydrofuran / 90 h

2: pyridine / 6 h / Ambient temperature

3: lithium chloride / dimethylformamide / 0.42 h / 80 °C

4: ammonium formate / 10percent Pd/C / tetrahydrofuran; methanol / 0.33 h / Ambient temperature

5: hydrogen chloride gas / ethyl acetate / 0.67 h

6: EDC / N,N-dimethyl-acetamide / 2.25 h / Ambient temperature

7: triethylamine / acetonitrile; H₂O / 0.25 h / Ambient temperature

With pyridine; hydrogenchloride; ammonium formate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; lithium chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja00168a003

Reference yield:

: 108867-95-4
((R)-5-Benzyloxy-3-methanesulfonyl-8-methyl-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indol-1-yl)-methanol

: 101134-70-7,104636-99-9,110352-06-2,128049-45-6
C₂₁H₁₇N₃O₂

Guidance literature:: Multi-step reaction with 8 steps

1: 3.4 M REDAL / tetrahydrofuran; toluene / 0.5 h / 85 °C

2: triethylamine / tetrahydrofuran / 90 h

3: pyridine / 6 h / Ambient temperature

4: lithium chloride / dimethylformamide / 0.42 h / 80 °C

5: ammonium formate / 10percent Pd/C / tetrahydrofuran; methanol / 0.33 h / Ambient temperature

6: hydrogen chloride gas / ethyl acetate / 0.67 h

7: EDC / N,N-dimethyl-acetamide / 2.25 h / Ambient temperature

8: triethylamine / acetonitrile; H₂O / 0.25 h / Ambient temperature

With pyridine; hydrogenchloride; ammonium formate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; lithium chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; water; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/ja00168a003

Reference yield:

: 112836-68-7
(R)-1,6-dihydro-1-(hydroxymethyl)-8-methyl-5-(phenylmethoxy)-benzo<1,2-b:4,3-b'>dipyrrole-3(2H)-carboxylic acid 1,1-dimethylethyl ester

: 101134-70-7,104636-99-9,110352-06-2,128049-45-6
C₂₁H₁₇N₃O₂

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / 6 h / Ambient temperature

2: lithium chloride / dimethylformamide / 0.42 h / 80 °C

3: ammonium formate / 10percent Pd/C / tetrahydrofuran; methanol / 0.33 h / Ambient temperature

4: hydrogen chloride gas / ethyl acetate / 0.67 h

5: EDC / N,N-dimethyl-acetamide / 2.25 h / Ambient temperature

6: triethylamine / acetonitrile; H₂O / 0.25 h / Ambient temperature

With pyridine; hydrogenchloride; ammonium formate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; lithium chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja00168a003