4-fluoro-N-methyl-N-(trifluoromethyl)aniline

Base Information

• Chemical Name: 4-fluoro-N-methyl-N-(trifluoromethyl)aniline
• CAS No.: 10219-07-5
• Molecular Formula: C₈H₇F₄N
• Molecular Weight: 193.144
• ChEMBL ID: CHEMBL4776693
• DSSTox Substance ID: DTXSID80475752
• Wikidata: Q82306519
• Mol file: 10219-07-5.mol

Synonyms:4-fluoro-N-methyl-N-(trifluoromethyl)aniline;10219-07-5;Benzenamine, 4-fluoro-N-methyl-N-(trifluoromethyl)-;CHEMBL4776693;DTXSID80475752;AM90459

Chemical Property of 4-fluoro-N-methyl-N-(trifluoromethyl)aniline

Chemical Property:

• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 193.05146188
• Heavy Atom Count: 13
• Complexity: 160

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C1=CC=C(C=C1)F)C(F)(F)F

Technology Process of 4-fluoro-N-methyl-N-(trifluoromethyl)aniline

There total 2 articles about 4-fluoro-N-methyl-N-(trifluoromethyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

4-fluoro-N-methylaniline (459-59-6) + tetramethylammonium trifluoromethanethiolate → 4-fluoro-N-methyl-N-(trifluoromethyl)aniline (10219-07-5)

Guidance literature:

4-fluoro-N-methylaniline; tetramethylammonium trifluoromethanethiolate; In dichloromethane; at 20 ℃; for 0.25h; Inert atmosphere;

With silver fluoride; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/acs.jmedchem.0c01457

Reference yield:

→ 4-fluoro-N-methyl-N-(trifluoromethyl)aniline (10219-07-5)

Guidance literature:

4-Fluor-N-methyl-N-Trichlorethyl-anilin, SbF3, -70grad;

Reference yield:

4-fluoro-N-methyl-N-(trifluoromethyl)aniline (10219-07-5) → C8H7F2NO

Guidance literature:

With water; In dimethyl sulfoxide; at 20 ℃; for 6h;

DOI:10.1021/acs.jmedchem.0c01457

upstream raw materials:

4-fluoro-N-methylaniline

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