Ethyl 4-phenyl-1-(3-phenylpropyl)piperidine-4-carboxylate

Base Information

Chemical Name:Ethyl 4-phenyl-1-(3-phenylpropyl)piperidine-4-carboxylate
CAS No.:102762-46-9
Molecular Formula:C23H29NO2
Molecular Weight:351.489
Hs Code.:
ChEMBL ID:CHEMBL2205325
DSSTox Substance ID:DTXSID90596846
Nikkaji Number:J549.070G
Pharos Ligand ID:LB6PPV4Q6QB6
Wikidata:Q82492221
Mol file:102762-46-9.mol

Synonyms:CHEMBL2205325;102762-46-9;Ethyl 4-phenyl-1-(3-phenylpropyl)piperidine-4-carboxylate;SCHEMBL7313939;DTXSID90596846;JIUNTGIKLXHBHH-UHFFFAOYSA-N;BDBM50401666;Ethyl 1-(3-phenylpropyl)-4-phenyl-4-piperidine-carboxylate

Suppliers and Price of Ethyl 4-phenyl-1-(3-phenylpropyl)piperidine-4-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl 4-phenyl-1-(3-phenylpropyl)piperidine-4-carboxylate

Chemical Property:

XLogP3:4.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:8
Exact Mass:351.219829168
Heavy Atom Count:26
Complexity:416

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1(CCN(CC1)CCCC2=CC=CC=C2)C3=CC=CC=C3

Technology Process of Ethyl 4-phenyl-1-(3-phenylpropyl)piperidine-4-carboxylate

There total 7 articles about Ethyl 4-phenyl-1-(3-phenylpropyl)piperidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 77-17-8
Normeperidine

: 637-59-2
1-Bromo-3-phenylpropane

: 102762-46-9
4-phenyl-1-(3-phenyl-propyl)-piperidine-4-carboxylic acid ethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; at 140 ℃; for 1.33333h; Inert atmosphere; Microwave irradiation;
DOI:10.1016/j.bmcl.2012.09.080

Reference yield:

: 637-59-2
1-Bromo-3-phenylpropane

: 24465-45-0
ethyl 4-phenyl-4-piperidinecarboxylate hydrochloride

: 102762-46-9
4-phenyl-1-(3-phenyl-propyl)-piperidine-4-carboxylic acid ethyl ester

Guidance literature:: With sodium carbonate; butan-1-ol;
DOI:10.1021/ja01565a050

Reference yield:

: 40481-13-8
4-phenyl-4-cyanopiperidine

: 102762-46-9
4-phenyl-1-(3-phenyl-propyl)-piperidine-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃ / dimethylformamide

2: H₂SO₄ / Heating

With sulfuric acid; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.12.042